Product image of Ibuprofen Pharmaclan (Ibuprofen) supplied by GNH India

Ibuprofen Pharmaclan

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Pharmaclan (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Pharmaclan, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It belongs to the analgesic, antipyretic, and anti‑inflammatory therapeutic class and is employed to relieve mild to moderate pain, reduce fever, and diminish inflammation in adults and children when indicated.

GNH India supplies Ibuprofen Pharmaclan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance with EU standards and through reliable logistics.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Ibuprofen is an NSAID that reduces pain, fever, and inflammation by inhibiting prostaglandin synthesis.
  • Pain: provides relief of mild to moderate nociceptive pain.
  • Fever: lowers elevated body temperature associated with infectious or inflammatory processes.
  • Inflammation: diminishes swelling and discomfort in conditions such as musculoskeletal strain or arthritis.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin levels decreases peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature regulation, and limits inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

Adverse reactions may occur with ibuprofen use and vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Mild skin rash
  • Elevated blood pressure

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Acute renal failure or worsening of chronic kidney disease
  • Severe hypersensitivity reactions including anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Liver enzyme elevations or hepatitis
  • Cardiovascular thrombotic events such as myocardial infarction or stroke

Precautions & Warnings

  • Before initiating therapy, consider patient‑specific risk factors and monitor for adverse events.
  • Assess gastrointestinal risk: evaluate history of ulcer disease or concurrent NSAID use.
  • Evaluate renal function: adjust use in patients with impaired kidney function.
  • Monitor cardiovascular status: use lowest effective dose in patients with heart disease.
  • Use lowest effective dose: limit duration to the shortest period necessary for symptom control.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can alter the pharmacodynamics or pharmacokinetics of several co‑administered agents.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration.
  • ACE inhibitors or ARBs in renal impairment: possible reduction in renal function.
  • Lithium: increased serum lithium levels.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential reduction in antihypertensive effect.
  • Antihypertensives (e.g., beta‑blockers): may blunt blood pressure control.
  • Methotrexate: decreased renal clearance leading to toxicity.
  • SSRIs or SNRIs: elevated bleeding tendency.
  • Alcohol: synergistic gastric irritation and ulcer risk.

Frequently Asked Questions

Ibuprofen Pharmaclan is used to relieve mild to moderate pain, reduce fever, and lessen inflammation associated with conditions such as headaches, musculoskeletal aches, dental pain, and febrile illnesses. It belongs to the NSAID class and works by decreasing prostaglandin production, which mediates these symptoms.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This inhibition prevents the conversion of arachidonic acid into prostaglandins, which are responsible for pain signaling, fever generation, and inflammation. The resulting lower prostaglandin levels provide analgesic, antipyretic, and anti‑inflammatory effects.

The appropriate dose of Ibuprofen Pharmaclan is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage recommendations follow local regulatory guidelines and should be individualized for each patient.

Safety of ibuprofen during pregnancy and lactation depends on the trimester and clinical circumstances. It is generally avoided in the third trimester because of potential fetal cardiovascular effects. Breastfeeding mothers should consult a healthcare provider, as small amounts can pass into milk. Professional guidance is essential before use.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ibuprofen Pharmaclan shares the same mechanism of action as other non‑selective NSAIDs such as naproxen or diclofenac. Compared with some alternatives, ibuprofen has a relatively short half‑life, which may allow flexible dosing but may also require more frequent administration for sustained effect. Efficacy and safety profiles are comparable when used at recommended doses.

Ibuprofen Pharmaclan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain stability.

Ibuprofen Pharmaclan is taken orally, usually with a glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s instructions.

Serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, severe allergic reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke, especially with high‑dose or prolonged use. Patients should be monitored for these events and discontinue use if they occur.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, or those who have experienced a recent cardiovascular event should avoid using Ibuprofen Pharmaclan unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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