Product image of Ibuprofen/Pseudoephedrin (Pseudoephedrine Hydrochloride, Ibuprofen) supplied by GNH India

Ibuprofen/Pseudoephedrin

Active Ingredient:
Pseudoephedrine Hydrochloride, Ibuprofen
Origin:
EU

Ibuprofen/Pseudoephedrin (Pseudoephedrine Hydrochloride, Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen/Pseudoephedrine, is a non‑steroidal anti‑inflammatory drug presented as an oral formulation for systemic use. It provides analgesic, antipyretic and anti‑inflammatory effects and is combined with pseudoephedrine to relieve nasal congestion.
GNH India supplies Ibuprofen/Pseudoephedrine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

1
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Indications & Clinical Uses

  • Ibuprofen/Pseudoephedrine acts on pain, fever and nasal congestion pathways, offering combined relief for several common conditions.
  • Nasal congestion due to common cold: reduces swelling of nasal passages and improves airflow.
  • Sinusitis‑related headache: alleviates pain and pressure associated with sinus inflammation.
  • Fever and mild to moderate pain: lowers body temperature and eases discomfort.

How It Works

  • Ibuprofen inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing prostaglandin synthesis and thereby producing analgesic, antipyretic and anti‑inflammatory effects. Pseudoephedrine hydrochloride acts as an α‑adrenergic agonist, causing vasoconstriction of nasal mucosal blood vessels, which reduces edema and relieves nasal congestion.

Side Effects

Common Side Effects

  • Nausea or stomach upset
  • Dizziness or mild headache
  • Insomnia or restlessness
  • Increased heart rate

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Gastrointestinal bleeding or ulceration
  • Marked elevation of blood pressure
  • Cardiac arrhythmias or palpitations
  • Hallucinations or severe central nervous system effects
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

  • Before using this combination product, consider the following safety measures.
  • Assess cardiovascular status: pseudoephedrine may raise blood pressure.
  • Avoid use in patients with peptic ulcer disease: ibuprofen can exacerbate gastric irritation.
  • Monitor renal function: NSAIDs may affect kidney performance.
  • Consider drug interactions: avoid concurrent MAO inhibitors.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

When co‑administered with other medicines, ibuprofen/pseudoephedrine may require careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis with pseudoephedrine.
  • Anticoagulants (e.g., warfarin): increased bleeding risk with ibuprofen.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
  • Lithium: pseudoephedrine may raise serum lithium levels.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce the antihypertensive effect of pseudoephedrine.
  • ACE inhibitors: possible attenuation of blood‑pressure control.
  • Beta‑blockers: may blunt pseudoephedrine‑induced tachycardia.

Frequently Asked Questions

Ibuprofen/Pseudoephedrine is indicated for relief of nasal congestion caused by colds or sinusitis, for headaches associated with sinus pressure, and for reducing fever and mild to moderate pain such as aches, sore throat or muscle discomfort.

Ibuprofen blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins that mediate pain, fever and inflammation. This action provides analgesic, antipyretic and anti‑inflammatory benefits.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, weight, medical condition and other medications. Patients should follow the prescriber’s instructions and the product label.

Safety in pregnancy and lactation has not been fully established. Healthcare providers usually weigh the potential benefits against possible risks before prescribing. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient ibuprofen, the addition of pseudoephedrine adds nasal decongestion, making the combination useful when pain or fever co‑exists with congestion. Unlike pure decongestants, it also addresses pain and fever, offering a broader symptom‑relief profile.

Store the product at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Do not refrigerate or freeze unless the label specifically indicates otherwise.

The medication is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help reduce stomach irritation. Follow the prescriber’s dosing schedule.

Serious risks include severe allergic reactions such as anaphylaxis, gastrointestinal bleeding or ulceration, significant elevation of blood pressure, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience symptoms like swelling of the face, difficulty breathing, vomiting blood, or a sudden, severe headache.

Individuals with known hypersensitivity to ibuprofen, pseudoephedrine, or any NSAID should not use this product. It is also contraindicated in patients with uncontrolled hypertension, active peptic ulcer disease, severe heart disease, or those taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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