Product image of Ibuprofen S&r (Ibuprofen) supplied by GNH India

Ibuprofen S&r

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen S&r (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen S&r, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for oral use. It treats pain, fever and inflammation in adults and children as appropriate.

GNH India supplies Ibuprofen S&r as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

S&r Farmaceutici

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces pain, fever, and inflammation by inhibiting prostaglandin synthesis.

  • Headache: provides relief of mild to moderate headache pain.
  • Musculoskeletal pain: reduces pain and swelling associated with strains, sprains and arthritis.
  • Fever: lowers elevated body temperature in febrile conditions.

How It Works

  • Ibuprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin levels diminish peripheral sensitisation of nociceptors, lower fever set‑point in the hypothalamus, and limit inflammatory exudate formation, resulting in analgesic, antipyretic and anti‑inflammatory effects.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or heartburn.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure.
  • Tinnitus (ringing in ears).

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment or failure.
  • Severe allergic reactions such as anaphylaxis.
  • Hepatotoxicity with elevated liver enzymes.
  • Thrombocytopenia or other blood dyscrasias.

Precautions & Warnings

Before using Ibuprofen S&r, consider the following safety measures.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Monitor renal function: use cautiously in those with renal impairment.
  • Avoid concurrent anticoagulants: increased risk of bleeding.
  • Limit use in cardiovascular disease: may raise risk of thrombotic events.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with several medication classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: heightened cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Diuretics: risk of renal impairment.
  • Lithium: increased serum lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ibuprofen S&r is an over‑the‑counter NSAID indicated for the relief of mild to moderate pain, reduction of fever, and control of inflammation associated with conditions such as headache, musculoskeletal aches, and febrile illnesses.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins. Lower prostaglandin levels decrease pain signalling, lower the hypothalamic set‑point for temperature, and limit inflammatory processes.

The appropriate dose of ibuprofen is determined by a prescriber or according to the product label. Dosage depends on the patient’s age, weight, clinical condition, and response, and should never exceed the maximum daily amount recommended on the packaging.

Safety of ibuprofen in pregnancy and lactation is not fully established. It should be used only if clearly needed and after consultation with a healthcare professional, especially during the third trimester or while nursing, where alternative therapies may be preferred.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen provides analgesic, antipyretic and anti‑inflammatory effects, whereas acetaminophen (paracetamol) offers mainly analgesic and antipyretic actions without significant anti‑inflammatory activity. Ibuprofen also carries a higher risk of gastrointestinal and renal side effects, while acetaminophen is associated with hepatic toxicity at excessive doses.

Store Ibuprofen S&r at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight and excessive heat to maintain stability and potency.

Ibuprofen S&r is taken orally, usually with a glass of water. It can be taken with or without food; however, taking it with food or milk may reduce the likelihood of gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulcer perforation, acute kidney injury, severe allergic reactions such as anaphylaxis, and cardiovascular events like heart attack or stroke, particularly with high‑dose or prolonged use.

Individuals with active peptic ulcer disease, severe renal or hepatic impairment, known hypersensitivity to ibuprofen or other NSAIDs, and those in the third trimester of pregnancy should avoid ibuprofen unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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