Ibuprofen Strides Pharma Uk (Ibuprofen)

Ibuprofen acts on the cyclooxygenase pathway to provide analgesic, antipyretic and anti‑inflammatory effects.

• Pain: reduces mild to moderate acute pain such as headache, dental or musculoskeletal discomfort.
• Fever: lowers elevated body temperature associated with viral or bacterial infections.
• Inflammation: diminishes swelling and redness in soft‑tissue injuries.
• Arthritis: alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

• Ibuprofen reversibly inhibits the cyclooxygenase enzymes COX‑1 and COX‑2, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation.

Common Side Effects

• Dyspepsia: mild stomach discomfort or heartburn.
• Nausea: feeling of queasiness.
• Dizziness: transient light‑headedness.
• Headache: mild to moderate head pain.
• Rash: transient skin redness or itching.
• Diarrhoea: loose stools.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Severe allergic reactions such as anaphylaxis.
• Hepatic enzyme elevation indicating liver stress.
• Acute kidney injury, especially with dehydration.
• Cardiovascular events including myocardial infarction or stroke.
• Blood dyscrasias such as thrombocytopenia.

Ibuprofen should be used with caution in specific clinical situations.

• Renal function assessment: evaluate kidney status before initiating therapy.
• Gastro‑intestinal risk: avoid in patients with a history of ulcers or bleeding.
• Dose minimisation: use the lowest effective dose for the shortest duration.
• Hypersensitivity: discontinue if signs of allergic reaction appear.
• Pregnancy: avoid in the third trimester unless clearly indicated.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Ibuprofen can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or high‑dose aspirin: additive gastrointestinal toxicity.
• ACE inhibitors or ARBs: may reduce renal perfusion.

Moderate Interactions (Monitor Closely)

• Diuretics: possible reduction in antihypertensive effect.
• Methotrexate: decreased clearance leading to toxicity.
• Lithium: increased serum lithium concentrations.