Product image of Ibuprofen Zentiva (Ibuprofen) supplied by GNH India

Ibuprofen Zentiva

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Zentiva (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Zentiva, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It treats mild to moderate pain, fever, and inflammatory conditions such as arthritis in adults and children as appropriate.

GNH India supplies Ibuprofen Zentiva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Ibuprofen acts as an NSAID to reduce inflammation and pain across several common conditions.

  • Mild to moderate pain: provides analgesia for headaches, dental pain, musculoskeletal discomfort, and postoperative pain.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Arthritis: alleviates joint pain and swelling in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen inhibits cyclooxygenase enzymes COX-1 and COX-2, which reduces the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever generation, providing symptomatic relief in a variety of acute and chronic conditions.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dyspepsia: indigestion or heartburn.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Rash: mild skin irritation or redness.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe allergic reaction (anaphylaxis, angioedema).
  • Renal impairment or acute kidney injury.
  • Hepatic enzyme elevation or liver injury.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Hematologic abnormalities (e.g., thrombocytopenia).

Precautions & Warnings

Before using Ibuprofen, consider the following safety measures.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Use the lowest effective dose: limit exposure to reduce adverse events.
  • Monitor renal function: especially in patients with kidney disease or dehydration.
  • Avoid in third trimester pregnancy: risk to fetal cardiovascular system.
  • Take with food or milk: helps minimise stomach irritation.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential.
  • Lithium: higher serum lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in renal perfusion.

  • ACE inhibitors or ARBs: may impair renal function.
  • Beta‑blockers: potential for reduced antihypertensive effect.
  • Oral hypoglycemics: may affect blood glucose control.
  • Corticosteroids: additive risk of gastrointestinal ulceration.

Frequently Asked Questions

Ibuprofen Zentiva is an oral NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It is commonly prescribed when a non‑opioid analgesic and anti‑inflammatory effect is required.

Ibuprofen works by inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for the synthesis of prostaglandins. By lowering prostaglandin production, it reduces inflammation, diminishes pain signaling, and helps lower elevated body temperature.

The specific dose of Ibuprofen Zentiva is determined by the prescribing healthcare professional based on the patient’s age, condition, and response to therapy. Dosage recommendations follow established clinical guidelines and should be individualized for each patient.

Ibuprofen should be used with caution during pregnancy, especially in the third trimester, due to potential risks to the fetus. While short‑term use may be considered in the first two trimesters under medical advice, breastfeeding mothers should consult a clinician because ibuprofen can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen shares a similar mechanism of action with other NSAIDs such as naproxen and diclofenac, but it differs in pharmacokinetic profile, dosing frequency, and individual tolerability. Compared with aspirin, ibuprofen has a lower risk of gastric irritation at standard doses, while providing comparable analgesic efficacy.

Ibuprofen Zentiva should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keeping the product in a dry, cool place helps maintain its stability and potency throughout its shelf life.

Ibuprofen Zentiva is taken orally, usually with a full glass of water. It can be swallowed with or without food; however, taking it with meals or milk may reduce the likelihood of gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, renal impairment, and increased cardiovascular events like heart attack or stroke, particularly with high‑dose or prolonged use. Patients should be monitored for these events and seek immediate medical attention if they occur.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulceration, severe heart failure, or in the third trimester of pregnancy should avoid using Ibuprofen Zentiva. It is also contraindicated in patients with significant renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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