Product image of Ibuprofen Zentiva (Ibuprofen) supplied by GNH India

Ibuprofen Zentiva

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Zentiva (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Zentiva, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve pain, reduce fever, and lessen inflammation in adults and children when appropriate.
GNH India supplies Ibuprofen Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ibuprofen Zentiva belongs to the NSAID class and acts on inflammatory pathways to provide symptomatic relief.

  • Pain: Relieves mild to moderate pain such as headache, dental pain, menstrual cramps, or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with common infections or inflammatory conditions.
  • Inflammation: Decreases swelling and stiffness in conditions like arthritis, sprains, or soft‑tissue injuries.

How It Works

  • Ibuprofen exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitization, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

Adverse reactions may occur with any NSAID, including ibuprofen.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

  • Gastrointestinal bleeding, ulceration, or perforation.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome.
  • Hepatotoxicity presenting as jaundice or abnormal liver enzymes.
  • Increased risk of cardiovascular events, especially with high‑dose or prolonged use.

Precautions & Warnings

Before using ibuprofen, consider the following safety measures.

  • Assess renal function: avoid use in patients with severe kidney disease.
  • Evaluate gastrointestinal risk: use the lowest effective dose in those with a history of ulcers or bleeding.
  • Use the minimum effective dose for the shortest duration required.
  • Avoid use in the third trimester of pregnancy due to fetal risks.
  • Monitor for signs of hypersensitivity, especially after the first dose.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration and bleeding.
  • Lithium: ibuprofen may raise lithium serum concentrations.
  • SSRIs (e.g., sertraline): enhanced bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
  • Diuretics: may impair renal clearance of ibuprofen.
  • Methotrexate: ibuprofen can decrease renal elimination, raising toxicity risk.
  • Cyclosporine: increased nephrotoxicity potential.
  • Antihypertensive agents: monitor blood pressure for possible attenuation.

Frequently Asked Questions

Ibuprofen Zentiva is indicated for the relief of mild to moderate pain, reduction of fever, and mitigation of inflammation. It is commonly employed for headaches, dental pain, menstrual cramps, musculoskeletal aches, and febrile states associated with infections or inflammatory disorders.

Ibuprofen works by reversibly blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. By lowering prostaglandin levels, it reduces the sensitization of pain receptors, lowers the hypothalamic set‑point for temperature, and limits the inflammatory cascade, providing analgesic, antipyretic, and anti‑inflammatory effects.

The appropriate dose of Ibuprofen Zentiva is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Patients should follow the prescriber’s instructions and the product labeling for dosing frequency and duration.

Safety of ibuprofen in pregnancy depends on the trimester. It is generally avoided in the third trimester because of potential fetal complications. Use during the first and second trimesters should be under medical supervision. Ibuprofen passes into breast milk in small amounts; breastfeeding mothers should consult a healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain needs), and assists with import documentation.

Ibuprofen shares a similar mechanism of action with other NSAIDs such as naproxen and diclofenac, providing analgesic, antipyretic, and anti‑inflammatory effects. Compared with some NSAIDs, ibuprofen has a relatively shorter half‑life, which may allow for flexible dosing but may also require more frequent administration for sustained relief.

Ibuprofen Zentiva should be stored at room temperature, below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture, heat, and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ibuprofen Zentiva is taken orally, usually with a full glass of water. It may be taken with or without food; however, taking it with food or milk can help reduce gastrointestinal discomfort. Patients should swallow tablets whole and not crush or chew them unless instructed otherwise.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, acute kidney injury, and increased cardiovascular events (e.g., heart attack or stroke) especially with high doses or prolonged use. Patients should seek immediate medical attention if they experience signs of bleeding, severe rash, swelling, or chest pain.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, patients in the third trimester of pregnancy, and persons with severe renal or hepatic impairment should avoid ibuprofen unless directed by a physician. Caution is also advised for patients on anticoagulants or certain antihypertensive therapies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.