Product image of Ibuprofen Zentiva (Ibuprofen) supplied by GNH India

Ibuprofen Zentiva

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Zentiva (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Zentiva, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is used to relieve pain, reduce fever, and lessen inflammation in adults and children when appropriate.
GNH India supplies Ibuprofen Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Ibuprofen Zentiva is an NSAID that acts on the cyclooxygenase pathway to manage common inflammatory conditions.

  • Pain: provides analgesia for mild to moderate musculoskeletal and dental pain.
  • Fever: lowers elevated body temperature associated with viral or bacterial infections.
  • Inflammation: reduces swelling and stiffness in conditions such as arthritis or soft‑tissue injury.

How It Works

  • Ibuprofen exerts its effect by reversibly inhibiting both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This non‑selective inhibition decreases the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation, pain signaling, and fever generation throughout the body.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort such as nausea or dyspepsia.
  • Headache or mild dizziness.
  • Transient rash or itching.
  • Mild elevation of liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment, especially in volume‑depleted patients.
  • Severe hypersensitivity reactions, including anaphylaxis.
  • Hepatotoxicity with marked liver enzyme rise.
  • Hematologic abnormalities such as thrombocytopenia.

Precautions & Warnings

Before using Ibuprofen Zentiva, consider the following safety measures.

  • Assess renal function: evaluate baseline kidney status, especially in elderly or dehydrated patients.
  • Review gastrointestinal risk: avoid in individuals with active ulcers or a history of GI bleeding.
  • Monitor cardiovascular health: use cautiously in patients with hypertension or heart disease.
  • Avoid use during the third trimester of pregnancy: consult a healthcare professional for alternatives.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • High‑dose aspirin: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal protective effects.
  • Diuretics: potential for reduced kidney function.
  • Lithium: ibuprofen can raise lithium serum concentrations.

Frequently Asked Questions

Ibuprofen Zentiva is an over‑the‑counter NSAID indicated for the temporary relief of mild to moderate pain, reduction of fever, and mitigation of inflammation associated with conditions such as musculoskeletal aches, dental pain, and arthritic swelling.

Ibuprofen works by reversibly blocking the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. Lower prostaglandin levels diminish pain signaling, reduce fever, and limit inflammatory swelling.

The appropriate dose of Ibuprofen Zentiva is determined by a prescriber or according to the product labeling. Dosage depends on the patient’s age, weight, clinical condition, and any relevant medical history, and should not exceed the maximum daily limit recommended for ibuprofen.

Ibuprofen should be avoided in the third trimester of pregnancy because it may affect fetal cardiovascular development. During the first and second trimesters, use only if clearly needed and after consulting a healthcare professional. It passes into breast milk in small amounts; nursing mothers should seek medical advice before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Ibuprofen shares a similar mechanism with other non‑selective NSAIDs such as naproxen and diclofenac, but it generally has a shorter half‑life, allowing flexible dosing. Its safety profile is comparable, though individual tolerance, gastrointestinal risk, and renal considerations may influence the choice of agent.

Ibuprofen Zentiva should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, excessive heat, and direct sunlight to maintain potency and stability.

Ibuprofen Zentiva is taken orally, usually with a glass of water. It can be taken with or without food; however, taking it with food or milk may reduce the likelihood of gastrointestinal discomfort.

The most serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, acute kidney injury, and cardiovascular events in high‑risk patients. Prompt medical attention is required if any of these serious symptoms occur.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, and patients in the third trimester of pregnancy should avoid using Ibuprofen Zentiva unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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