Ibuprofene Eg Labo Conseil (Ibuprofen)

Ibuprofen, an NSAID that inhibits prostaglandin synthesis, is indicated for the following conditions:

• Musculoskeletal pain (e.g., backache, sprains): helps lessen pain intensity and improve mobility.
• Fever associated with infections or inflammatory conditions: lowers elevated body temperature toward normal.
• Inflammatory disorders such as arthritis: reduces joint swelling and stiffness.

• Ibuprofen exerts its therapeutic effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition reduces the conversion of arachidonic acid to prostaglandins, thereby decreasing the mediators responsible for pain sensation, fever generation, and inflammation at the site of tissue injury.

Common Side Effects

• Gastrointestinal discomfort or dyspepsia.
• Nausea or vomiting.
• Headache.
• Dizziness.
• Mild skin rash.
• Elevated blood pressure.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Acute renal failure or worsening of chronic kidney disease.
• Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome.
• Hepatotoxicity with elevated liver enzymes.
• Cardiovascular events including myocardial infarction or stroke.
• Thrombocytopenia or other blood dyscrasias.

Before initiating therapy, consider the following precautions:

• Assess renal function: avoid use in patients with severe renal impairment.
• Review gastrointestinal history: employ the lowest effective dose in those with prior ulcer disease.
• Avoid concomitant anticoagulants: increased risk of bleeding.
• Use caution in asthma: ibuprofen may precipitate bronchospasm.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at ambient temperature below 25 °C: keep in the original container, protect from moisture and light.

Ibuprofen may interact with several medicines. Review the following groups:

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened bleeding risk.
• Selective serotonin reuptake inhibitors (SSRIs): increased hemorrhage potential.
• Corticosteroids: additive gastrointestinal toxicity.
• Lithium: possible elevation of serum lithium concentrations.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal function, especially in volume‑depleted patients.
• Diuretics: risk of renal impairment when combined.
• Methotrexate: ibuprofen can decrease methotrexate clearance, raising toxicity risk.