Product image of Ibuprofene Pensavital (Ibuprofen) supplied by GNH India

Ibuprofene Pensavital

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofene Pensavital (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofene Pensavital, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve pain, reduce fever, and lessen inflammation in adults and children when appropriate.

GNH India supplies Ibuprofene Pensavital as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution and regulatory support.

Manufacturer / TM Owner

Towa Pharmaceutical S.P.A.

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Pain: alleviates mild to moderate nociceptive pain such as headache, dental pain, or musculoskeletal discomfort.
  • Fever: reduces elevated body temperature associated with viral or bacterial infections.
  • Inflammation: diminishes inflammatory response in conditions like osteoarthritis, rheumatoid arthritis, or soft‑tissue injuries.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which catalyze the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it lowers the inflammatory mediators that sensitize nerve endings, thereby providing analgesic, antipyretic, and anti‑inflammatory actions. The inhibition is reversible and occurs throughout peripheral tissues and the central nervous system.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: ulceration or hemorrhage in the stomach or intestines.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Cardiovascular events: increased risk of heart attack or stroke, especially with high doses.
  • Severe allergic reaction: anaphylaxis, angioedema, or bronchospasm.

Precautions & Warnings

When using ibuprofen, several precautions should be observed to minimize risks.

  • Assess renal function: avoid use in patients with severe kidney disease or dehydration.
  • Evaluate gastrointestinal risk: consider protective agents for individuals with history of ulcers or bleeding.
  • Monitor cardiovascular status: use cautiously in patients with hypertension, heart disease, or stroke risk.
  • Review concomitant medications: avoid concurrent use with other NSAIDs, anticoagulants, or corticosteroids without medical guidance.
  • Pregnancy and lactation: limit use during the third trimester and consult a healthcare professional if breastfeeding.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering their effectiveness or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • High‑dose aspirin: enhanced renal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and affect kidney function.
  • Diuretics: possible decrease in renal perfusion.
  • Lithium: increased lithium levels leading to toxicity.
  • Methotrexate: reduced clearance, raising risk of toxicity.

Frequently Asked Questions

Ibuprofene Pensavital contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, lower fever, and reduce inflammation associated with conditions such as headaches, dental pain, musculoskeletal aches, and arthritic disorders. It provides symptomatic relief when prescribed by a healthcare professional.

Ibuprofen works by non‑selectively blocking the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition reduces the production of prostaglandins, which are chemical mediators that promote inflammation, pain, and fever. Lower prostaglandin levels result in decreased sensitivity of nerve endings and reduced temperature set‑points in the brain.

The appropriate dose of Ibuprofene Pensavital is determined by the prescribing clinician based on the patient’s age, weight, medical condition, and response to therapy. Healthcare providers follow established dosing guidelines for ibuprofen, but the exact regimen should always be confirmed with the prescriber.

Ibuprofen should be used with caution during pregnancy, especially in the third trimester, because it may affect fetal cardiovascular development. While limited data exist for breastfeeding, small amounts can pass into milk. Women who are pregnant or nursing should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain needs), and necessary import documentation.

Ibuprofene Pensavital (ibuprofen) offers a balance of analgesic, antipyretic, and anti‑inflammatory effects with a relatively short half‑life, allowing flexible dosing. Compared with naproxen, ibuprofen has a quicker onset but may require more frequent dosing. Unlike acetaminophen, ibuprofen also reduces inflammation but carries a higher gastrointestinal risk.

Store Ibuprofene Pensavital at ambient temperature, preferably below 25 °C. Keep the product in its original packaging to protect it from moisture and direct sunlight. Do not store in areas with high humidity or extreme heat, and keep it out of reach of children.

Ibuprofene Pensavital is taken orally, usually with a full glass of water. It can be taken with or without food; however, taking it with food or milk may lessen gastrointestinal discomfort. The tablet should be swallowed whole and not chewed or crushed unless directed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, especially in patients with a history of ulcers or who use anticoagulants. Renal impairment can occur, particularly in dehydrated individuals or those with pre‑existing kidney disease. Cardiovascular events such as heart attack or stroke may be heightened with high‑dose or long‑term use, and severe allergic reactions like anaphylaxis are possible.

Ibuprofene Pensavital should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, patients with severe renal or hepatic impairment, and women in the third trimester of pregnancy. It is also contraindicated in children under the age or weight limits specified by local regulatory guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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