Product image of Ibuprofene Zentiva (Ibuprofen) supplied by GNH India

Ibuprofene Zentiva

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofene Zentiva (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofene Zentiva, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It reduces pain, fever, and inflammation and is commonly used in adults and children for short‑term symptom relief.

GNH India supplies Ibuprofene Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, ensuring quality assurance and regulatory compliance across global markets. The product meets EU standards and is available for bulk procurement under established trade agreements.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces prostaglandin‑mediated pain, fever, and inflammation.

  • Pain: provides analgesic relief for headaches, dental pain, and musculoskeletal discomfort.
  • Fever: lowers elevated body temperature in febrile conditions.
  • Inflammatory disorders: alleviates swelling and stiffness in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and decreases inflammatory exudate formation.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment, especially in volume‑depleted patients.
  • Hepatic injury presenting as elevated transaminases.
  • Severe hypersensitivity reactions, including anaphylaxis.
  • Dermatologic emergencies such as Stevens‑Johnson syndrome.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: avoid use in severe renal impairment.
  • Monitor gastrointestinal risk: co‑administer with food in patients with a history of ulcers.
  • Avoid in known hypersensitivity: discontinue immediately if allergic signs appear.
  • Use caution with anticoagulants: increased risk of bleeding.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofene Zentiva may interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Aspirin and other NSAIDs: additive gastrointestinal toxicity.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Selective serotonin reuptake inhibitors (SSRIs): increased potential for hemorrhage.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: risk of renal impairment when combined.
  • Lithium: NSAIDs may raise serum lithium concentrations.

Frequently Asked Questions

Ibuprofene Zentiva contains ibuprofen, an NSAID that is used to relieve mild to moderate pain, reduce fever, and diminish inflammation associated with conditions such as arthritis, dysmenorrhea, and acute musculoskeletal injuries.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which prevents the formation of prostaglandins that mediate pain, fever, and inflammatory responses.

The appropriate dose of Ibuprofene Zentiva is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy.

Safety in pregnancy and lactation should be evaluated by a qualified clinician. Ibuprofen is generally avoided in the third trimester of pregnancy and used with caution while breastfeeding, following professional guidance.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ibuprofene Zentiva offers the same pharmacological profile as other ibuprofen products, providing effective analgesic, antipyretic, and anti‑inflammatory actions. Compared with stronger NSAIDs like diclofenac, ibuprofen generally has a lower risk of cardiovascular events but shares similar gastrointestinal safety considerations.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from excessive moisture, direct sunlight, and heat to maintain potency throughout its shelf life.

Ibuprofene Zentiva is taken orally, usually with a full glass of water. It may be taken with food or milk to lessen gastrointestinal discomfort, unless otherwise directed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, acute kidney injury, and rare but serious skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience these symptoms.

Individuals with known hypersensitivity to ibuprofen or any NSAID, those with active gastrointestinal ulcers, severe renal or hepatic impairment, and patients in the third trimester of pregnancy should avoid using Ibuprofene Zentiva unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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