Product image of Ibuprofeno Amperlem 600 (Ibuprofen) supplied by GNH India

Ibuprofeno Amperlem 600

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofeno Amperlem 600 (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofeno Amperlem 600, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a 600 mg oral tablet for systemic use. It is indicated for mild to moderate pain, fever, and inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and dysmenorrhea.

GNH India supplies Ibuprofeno Amperlem 600 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide and complies with EU regulatory standards.

Manufacturer / TM Owner

Towa Pharmaceutical S.A.

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclo‑oxygenase enzymes.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, and musculoskeletal discomfort.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Osteoarthritis: decreases joint inflammation and improves functional mobility.
  • Rheumatoid arthritis: helps control chronic inflammatory joint pain and swelling.
  • Dysmenorrhea: relieves menstrual cramps and associated pelvic pain.

How It Works

  • Ibuprofen exerts its effect by reversibly inhibiting both cyclo‑oxygenase‑1 (COX‑1) and cyclo‑oxygenase‑2 (COX‑2) enzymes. This blockade reduces the conversion of arachidonic acid to prostaglandins and thromboxanes, leading to decreased synthesis of mediators that promote inflammation, pain, and fever. The inhibition is dose‑dependent and temporary, allowing normal enzyme activity to resume after the drug is cleared.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: may present as black stools or vomiting blood.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Severe hypersensitivity: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing ibuprofen, several safety considerations should be reviewed.

  • Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
  • Gastrointestinal protection: use with caution in individuals with a history of ulcer disease or bleeding.
  • Renal function: monitor kidney parameters in patients with chronic kidney disease or dehydration.
  • Concomitant anticoagulants: assess bleeding risk when combined with warfarin, aspirin, or other antithrombotics.
  • Pregnancy and lactation: use only if clearly needed after evaluating benefits and risks.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • High‑dose aspirin: enhanced gastrointestinal toxicity.
  • SSRIs: heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may blunt antihypertensive effect and affect renal function.
  • Methotrexate: reduced clearance, risk of toxicity.
  • Diuretics: possible decrease in renal perfusion.

Frequently Asked Questions

Ibuprofeno Amperlem 600 contains ibuprofen, an NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and dysmenorrhea. It is prescribed when a systemic anti‑inflammatory and analgesic effect is required.

Ibuprofen works by reversibly inhibiting the cyclo‑oxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the conversion of arachidonic acid into prostaglandins and thromboxanes, which are key mediators of inflammation, pain, and fever. By lowering prostaglandin levels, ibuprofen reduces these symptoms.

The appropriate dose of Ibuprofeno Amperlem 600 is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

Ibuprofen’s pregnancy category is not definitively established, and its use is generally avoided in the third trimester because of potential fetal risks. During breastfeeding, small amounts may pass into milk; therefore, it should be used only if the benefit outweighs the potential risk, after consulting a healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details and any required import documentation.

Ibuprofen is a non‑selective NSAID, whereas alternatives such as naproxen have a longer half‑life and may require less frequent dosing. Acetaminophen provides analgesia and antipyresis without anti‑inflammatory activity and lacks the gastrointestinal and cardiovascular risks associated with NSAIDs. Choice depends on the therapeutic goal and patient risk profile.

Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Ibuprofeno Amperlem 600 is taken orally with a full glass of water. It may be taken with or without food; however, taking it with food can reduce the likelihood of gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, renal impairment leading to reduced kidney function, and severe hypersensitivity reactions like anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice black stools, vomiting blood, sudden swelling, or difficulty breathing.

Ibuprofen should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe heart failure, uncontrolled hypertension, and in patients who have had a recent coronary artery bypass graft. It is also contraindicated in the third trimester of pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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