Ibuprofeno (Arginina) Cinfa (Ibuprofen)

Ibuprofen is an NSAID that reduces pain, fever and inflammation by inhibiting prostaglandin synthesis.

• Pain: provides analgesic relief for mild to moderate acute pain such as headache, dental pain or musculoskeletal discomfort.
• Fever: lowers elevated body temperature in febrile conditions.
• Inflammation: diminishes swelling and discomfort in inflammatory disorders like arthritis or soft‑tissue injuries.

• Ibuprofen exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin levels decrease inflammation, lower fever, and diminish the perception of pain at peripheral nerve endings.

Adverse reactions may vary in frequency and severity.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain.
• Headache: transient mild to moderate headache.
• Dizziness: occasional light‑headed sensation.
• Rash: mild skin erythema or itching.

Serious or Rare Side Effects

• Gastrointestinal bleeding: ulceration or hemorrhage requiring medical attention.
• Renal impairment: reduced kidney function, especially with prolonged use.
• Severe allergic reactions: anaphylaxis, angioedema or Stevens‑Johnson syndrome.

Before using ibuprofen, consider the following safety measures.

• Cardiovascular risk: avoid prolonged high‑dose use in patients with heart disease or hypertension.
• Gastrointestinal history: use cautiously in individuals with a history of ulcers or bleeding.
• Renal function: monitor kidney function in patients with pre‑existing renal impairment.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
• Drug interactions: review concomitant medications for potential interactions.
• Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors: additive renal and cardiovascular risk.

Moderate Interactions (Monitor