Ibuprofeno B. Braun (Ibuprofen)

Ibuprofen is an NSAID that reduces pain, fever and inflammation by inhibiting cyclooxygenase enzymes.

• Pain: provides analgesia for mild to moderate acute pain.
• Fever: lowers elevated body temperature in febrile states.
• Inflammation: decreases swelling associated with inflammatory conditions.
• Postoperative pain: manages discomfort after surgical procedures.

• Ibuprofen reversibly inhibits both COX‑1 and COX‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and curtails inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory effects.

Adverse reactions may occur with any ibuprofen injection. The following lists observed events.

Common Side Effects

• Nausea: mild to moderate upset stomach.
• Dyspepsia: discomfort or burning in the upper abdomen.
• Headache: transient cranial pain.
• Dizziness: sensation of light‑headedness.
• Injection site pain: local discomfort at the IV site.
• Mild rash: transient skin redness.

Serious or Rare Side Effects

• Gastrointestinal bleeding: potentially life‑threatening hemorrhage.
• Renal impairment: reduced kidney function or acute failure.
• Anaphylaxis: severe allergic reaction with airway compromise.
• Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
• Thrombocytopenia: low platelet count leading to bleeding.
• Hepatic necrosis: serious liver injury.

Before using ibuprofen injection, consider the following safety measures.

• Assess renal function: avoid or adjust dose in patients with impaired kidney function.
• Monitor gastrointestinal risk: use cautiously in individuals with active ulcers or a history of bleeding.
• Avoid in known hypersensitivity: contraindicated for patients allergic to ibuprofen or other NSAIDs.
• Use caution in cardiovascular disease: evaluate thrombotic risk before administration.
• Pregnancy and lactation: consult the prescriber as safety data are limited.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Ibuprofen may interact with several drug classes. Review the following.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and renal toxicity.
• Corticosteroids: heightened chance of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors: possible reduction in renal function.
• Diuretics (loop or thiazide): may exacerbate renal impairment.
• Lithium: ibuprofen can raise serum lithium concentrations.