Ibuprofeno Farmalider S.A. (Ibuprofen)

Ibuprofen acts as an NSAID to reduce inflammation and relieve symptoms across several common conditions.

• Pain: provides relief from mild to moderate acute or chronic pain.
• Fever: lowers elevated body temperature associated with infection or inflammation.
• Inflammation: diminishes swelling and redness in musculoskeletal tissues.
• Arthritis: alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

• Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, reducing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels decrease inflammation, pain signaling, and fever generation at the site of tissue injury or infection.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Nausea or upset stomach
• Heartburn or dyspepsia
• Headache
• Dizziness
• Mild skin rash
• Diarrhoea

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration
• Severe allergic reaction (anaphylaxis, angioedema)
• Acute kidney injury
• Elevated liver enzymes
• Cardiovascular events such as myocardial infarction
• Blood disorders like thrombocytopenia

Before using ibuprofen, consider the following safety measures.

• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
• Monitor renal function: use caution in individuals with impaired kidney function.
• Avoid in known hypersensitivity: discontinue if allergic reactions occur.
• Use lowest effective dose: limit duration to the shortest period needed for symptom control.
• Review concomitant anticoagulant therapy: assess bleeding risk when combined with blood thinners.
• Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
• Corticosteroids: additive risk of ulceration and bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): amplified bleeding tendency.
• Lithium: ibuprofen may raise lithium serum concentrations.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: may enhance renal adverse effects.
• Methotrexate: decreased clearance leading to toxicity.
• Antihypertensives: potential attenuation of blood‑pressure‑lowering effect.
• Alcohol: synergistic irritation of the gastric mucosa.