Product image of Ibuprofeno Pharma Combix (Ibuprofen) supplied by GNH India

Ibuprofeno Pharma Combix

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofeno Pharma Combix (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofeno Pharma Combix, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is indicated for the relief of pain, reduction of fever, and management of inflammation in adults and children when appropriate.

GNH India supplies Ibuprofeno Pharma Combix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Combix, S.L.U.

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Indications & Clinical Uses

Ibuprofeno Pharma Combix is an NSAID that acts on inflammatory pathways to relieve several common conditions.

  • Pain: Provides analgesic relief for mild to moderate acute or chronic pain.
  • Fever: Reduces elevated body temperature associated with infectious or inflammatory processes.
  • Inflammation: Decreases swelling and discomfort in soft tissues.
  • Arthritis: Alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce inflammation, pain signaling, and fever generation, producing its therapeutic effects across multiple tissues.

Side Effects

Adverse reactions may occur with ibuprofen use and vary in frequency and severity.

Common Side Effects

  • Nausea: Mild to moderate stomach upset.
  • Dyspepsia: Indigestion or heartburn.
  • Headache: Transient cranial discomfort.
  • Dizziness: Light‑headed sensation.
  • Rash: Mild skin irritation.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Acute renal impairment or failure.
  • Severe allergic reaction (anaphylaxis, angioedema).
  • Hepatotoxicity: Elevated liver enzymes or hepatitis.
  • Blood dyscrasias: Thrombocytopenia or neutropenia.

Precautions & Warnings

Before initiating therapy, consider patient‑specific risk factors and monitor appropriately.

  • Assess gastrointestinal risk: Use lowest effective dose and consider gastro‑protective agents in high‑risk patients.
  • Monitor renal function: Avoid in patients with severe renal impairment or dehydration.
  • Avoid in known hypersensitivity: Discontinue if allergic reactions develop.
  • Use with food or antacids: Reduces stomach irritation.
  • Limit duration: Prolonged use increases risk of adverse events.
  • Store at room temperature: Keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can alter the pharmacokinetics or pharmacodynamics of several medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Increased bleeding risk.
  • Other NSAIDs or aspirin: Additive gastrointestinal toxicity.
  • Corticosteroids: Heightened risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors (e.g., lisinopril): May reduce antihypertensive effect and impair renal function.
  • Selective serotonin reuptake inhibitors (e.g., sertraline): Potential for increased bleeding.
  • Diuretics (e.g., furosemide): May worsen renal insufficiency when combined.

Frequently Asked Questions

Ibuprofeno Pharma Combix is an oral ibuprofen product indicated for the relief of mild to moderate pain, reduction of fever, and control of inflammation such as that seen in arthritis, musculoskeletal injuries, and common colds.

Ibuprofen blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are required for prostaglandin synthesis. By lowering prostaglandin levels, it reduces inflammation, diminishes pain signals, and helps lower elevated body temperature.

The appropriate dose of Ibuprofeno Pharma Combix is determined by the prescribing healthcare professional based on the patient’s age, weight, condition being treated, and overall health status. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of ibuprofen in pregnancy and lactation depends on the trimester and individual risk factors. It is generally avoided in the third trimester and used only when clearly needed during earlier stages. Breastfeeding mothers should consult their physician, as small amounts may pass into milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofeno Pharma Combix contains ibuprofen, a widely used NSAID with a balanced profile of analgesic, antipyretic, and anti‑inflammatory activity. Compared with aspirin, it has a lower risk of gastric irritation at standard doses, and unlike selective COX‑2 inhibitors, it provides broader anti‑inflammatory effects but shares similar gastrointestinal cautions.

Store the tablets at room temperature, ideally below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not store in areas with high humidity or extreme heat.

Ibuprofeno Pharma Combix is taken orally with a full glass of water. It may be taken with food or milk to lessen stomach discomfort. Patients should swallow the tablet whole and avoid crushing or chewing unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, acute kidney injury, and cardiovascular events in susceptible individuals. Patients should seek immediate medical attention if they experience black stools, persistent vomiting, swelling of the face or throat, or sudden shortness of breath.

Individuals with a known hypersensitivity to ibuprofen or any other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, and patients who are in the third trimester of pregnancy should avoid using Ibuprofeno Pharma Combix unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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