Ibuprofeno Vegal (Ibuprofen)

Ibuprofeno Vegal, an NSAID, is used for several common pain‑related and inflammatory conditions.

• Mild to moderate pain: relief of musculoskeletal, dental or postoperative discomfort.
• Fever: reduction of elevated body temperature associated with infection or inflammation.
• Osteoarthritis and rheumatoid arthritis: alleviation of joint pain and swelling.
• Dysmenorrhea: mitigation of menstrual cramps and associated pain.
• Headache: alleviation of tension‑type or migraine‑associated headache pain.

• Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis leads to lowered inflammation, pain signalling and fever generation at peripheral and central sites.

Ibuprofeno Vegal may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

• Nausea: mild stomach upset after oral intake.
• Dyspepsia: heartburn or indigestion.
• Headache: transient headache episodes.
• Dizziness: occasional light‑headedness.
• Rash: mild skin irritation or itching.
• Diarrhoea: loose stools.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reaction (anaphylaxis).
• Liver enzyme elevation or hepatitis.
• Acute kidney injury or reduced renal function.
• Blood dyscrasias such as thrombocytopenia.
• Cardiovascular events in high‑risk patients.

Before using Ibuprofeno Vegal, consider the following safety measures.

• Assess gastrointestinal risk: avoid in patients with active ulcers or bleeding disorders.
• Use the lowest effective dose: limit duration to the shortest period needed for symptom control.
• Avoid in known hypersensitivity: discontinue if rash or bronchospasm occurs.
• Caution in renal or hepatic impairment: monitor function and adjust use accordingly.
• Pregnancy and breastfeeding: safety not established; consult a healthcare professional.
• Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Ibuprofeno Vegal can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened ulcer risk.
• ACE inhibitors or ARBs: potential renal impairment.
• Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in renal clearance.

• Antihypertensives: may blunt blood‑pressure‑lowering effect.
• Methotrexate: reduced clearance leading to toxicity.
• SSRIs: modest increase in bleeding tendency.
• Alcohol: enhanced gastric irritation and bleeding risk.