Product image of Ibuprofeno Zentiva (Ibuprofen) supplied by GNH India

Ibuprofeno Zentiva

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofeno Zentiva (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofeno Zentiva, is a nonsteroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It treats mild to moderate pain, fever and inflammatory conditions such as arthritis and is commonly used across adult populations, and may be recommended by healthcare professionals.

GNH India supplies Ibuprofeno Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Zentiva Spain S.L.U.

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Indications & Clinical Uses

Ibuprofen, a non‑steroidal anti‑inflammatory drug, reduces pain and inflammation by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, and musculoskeletal discomfort.
  • Fever: lowers elevated body temperature in adults and children.
  • Arthritis: decreases joint inflammation and improves mobility in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This blockade reduces the conversion of arachidonic acid to prostaglandins and thromboxanes, mediators responsible for pain, fever and inflammation. The decreased prostaglandin synthesis diminishes peripheral sensitization of nociceptors and lowers the hypothalamic set‑point for temperature regulation.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Rash or mild skin irritation.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute kidney injury or reduced renal function.
  • Severe hypersensitivity reactions such as anaphylaxis.
  • Hepatotoxicity with elevated liver enzymes.

Precautions & Warnings

When using ibuprofen, several safety considerations should be observed.

  • Assess renal function: adjust use in patients with kidney disease or dehydration.
  • Evaluate gastrointestinal risk: avoid in active ulcer disease or history of GI bleeding.
  • Monitor asthma status: ibuprofen may exacerbate bronchospasm in aspirin‑sensitive individuals.
  • Limit alcohol intake: concurrent use increases risk of gastric irritation and bleeding.
  • Use the lowest effective dose: minimize exposure while achieving therapeutic benefit.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • High‑dose aspirin: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Diuretics: potential for reduced renal perfusion.
  • Lithium: ibuprofen can raise lithium serum levels.
  • Methotrexate: may increase methotrexate toxicity.

Frequently Asked Questions

Ibuprofeno Zentiva contains ibuprofen, an NSAID that is indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It is commonly prescribed for headaches, dental pain, musculoskeletal discomfort, and febrile episodes.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid into prostaglandins, which are key mediators of pain, inflammation, and fever. Lower prostaglandin levels reduce peripheral sensitization of pain receptors and reset the hypothalamic temperature set‑point.

The appropriate dose of Ibuprofeno Zentiva is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage may vary for pain, fever, or inflammatory disorders, and the prescriber will provide specific instructions tailored to the individual.

Safety data for ibuprofen in pregnancy are limited. It is generally avoided during the third trimester because of potential effects on fetal cardiovascular function. During breastfeeding, small amounts may pass into milk; a risk‑benefit assessment by a healthcare provider is recommended before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Ibuprofeno Zentiva. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofeno Zentiva offers a well‑characterised safety and efficacy profile typical of ibuprofen, a short‑acting NSAID. Compared with longer‑acting agents such as naproxen, ibuprofen may have a quicker onset but requires more frequent dosing. Its gastrointestinal and cardiovascular risk is comparable to other non‑selective NSAIDs, and selection often depends on patient‑specific factors.

Store Ibuprofeno Zentiva at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and excessive heat. Do not store in the bathroom or near a kitchen sink where humidity is high.

Ibuprofeno Zentiva is taken orally, usually with a full glass of water. It can be taken with or without food; however, taking it with food or milk may reduce gastrointestinal discomfort. Swallow tablets whole; do not crush or chew unless the formulation specifically permits it.

Serious risks include gastrointestinal bleeding or ulcer perforation, acute kidney injury, severe allergic reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke, especially with high‑dose or prolonged use. Patients should seek immediate medical attention if they notice black stools, severe abdominal pain, sudden swelling, or breathing difficulties.

Ibuprofeno Zentiva should be avoided in individuals with a known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, or in the third trimester of pregnancy. Caution is also advised for patients with chronic kidney disease, asthma that is aspirin‑sensitive, or those taking anticoagulants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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