Product image of Ibustrin (Indobufen) supplied by GNH India

Ibustrin

Active Ingredient:
Indobufen
Origin:
EU

Ibustrin (Indobufen)

Indobufen, the active ingredient in Ibustrin, is a platelet aggregation inhibitor presented as an oral tablet for oral use. It is employed to reduce the risk of clot formation in patients at risk of thromboembolic events, including those with a history of myocardial infarction or ischemic stroke.

GNH India supplies Ibustrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pfizer Italia S.R.L.

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Indications & Clinical Uses

  • Ibustrin is used in the management of cardiovascular conditions where platelet aggregation contributes to disease.
  • Prevention of thromboembolic events: lowers the incidence of clot‑related complications in at‑risk patients.
  • Secondary prevention after myocardial infarction: reduces the chance of recurrent cardiac events.
  • Prevention of ischemic stroke: diminishes the risk of stroke caused by arterial thrombosis.

How It Works

  • Indobufen reversibly inhibits platelet cyclooxygenase, decreasing the synthesis of thromboxane A₂, a potent promoter of platelet aggregation. The reduction in thromboxane A₂ limits platelet clumping and the formation of arterial thrombi, providing antithrombotic protection.

Side Effects

Indobufen may be associated with a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: mild nausea, dyspepsia or abdominal pain.
  • Headache: transient mild to moderate headache.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Severe bleeding: gastrointestinal or intracranial hemorrhage requiring medical attention.
  • Thrombocytopenia: marked reduction in platelet count.
  • Severe allergic reaction: rash, angioedema or anaphylaxis.

Precautions & Warnings

  • When prescribing Ibustrin, clinicians should consider several safety measures to minimize risk.
  • Assess bleeding risk: evaluate history of hemorrhage before initiating therapy.
  • Monitor liver function: periodic liver enzyme tests are recommended.
  • Avoid in active peptic ulcer disease: contraindicated due to bleeding risk.
  • Use with caution in renal impairment: dose adjustment may be required.
  • Do not combine with other antiplatelet agents without supervision: increased bleeding potential.
  • Store at room temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Indobufen can interact with other medicines, altering its antiplatelet effect or bleeding risk.

Major Interactions (Avoid)

  • Concurrent anticoagulants (e.g., warfarin, heparin): markedly increased bleeding risk.
  • Co‑administration with non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened gastrointestinal bleeding.

Moderate Interactions (Monitor Closely)

  • Clopidogrel or other antiplatelet agents: additive antiplatelet effect, monitor for bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs): may increase bleeding tendency, observe patient.
  • ACE inhibitors: potential for hypotension, monitor blood pressure.

Frequently Asked Questions

Ibustrin contains indobufen, an oral antithrombotic that is prescribed to prevent thromboembolic events, to provide secondary prevention after a myocardial infarction, and to reduce the risk of ischemic stroke in patients with established cardiovascular risk.

Indobufen reversibly inhibits platelet cyclooxygenase, which decreases the synthesis of thromboxane A₂, a potent promoter of platelet aggregation. By lowering thromboxane A₂ levels, the drug reduces platelet clumping and the formation of arterial clots.

The dosage of Ibustrin is determined by the prescribing physician based on the individual’s clinical condition, renal and hepatic function, and concomitant therapies. Patients should follow the exact regimen provided on the prescription label.

Safety data for indobufen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Ibustrin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with aspirin, indobufen offers reversible cyclooxygenase inhibition and may have a lower incidence of gastrointestinal irritation, while still providing effective platelet inhibition. Unlike clopidogrel, it does not require metabolic activation, resulting in a more predictable onset of action.

Ibustrin tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Do not store in humid or excessively hot environments.

Ibustrin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare provider.

The most serious risks include severe or uncontrolled bleeding, such as gastrointestinal hemorrhage or intracranial bleed, and rare cases of thrombocytopenia or severe allergic reactions. Prompt medical attention is required if any of these events occur.

Ibustrin is contraindicated in patients with active bleeding, known hypersensitivity to indobufen or other platelet cyclooxygenase inhibitors, and those with untreated peptic ulcer disease. It should also be avoided in individuals for whom antiplatelet therapy is medically inadvisable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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