Product image of Ibuvalen (Ibuprofen) supplied by GNH India

Ibuvalen

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuvalen (Ibuprofen)

Ibuprofen, the active ingredient in Ibuvalen, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats mild to moderate pain, fever and inflammatory conditions in adults and children as directed by a healthcare professional.

GNH India supplies Ibuvalen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vitema S.A.

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Indications & Clinical Uses

Ibuprofen, an NSAID, reduces pain and inflammation by inhibiting prostaglandin synthesis.

  • Headache: relief of mild to moderate headache symptoms.
  • Dental pain: alleviation of pain following dental procedures.
  • Musculoskeletal pain: reduction of discomfort from strains, sprains and arthritis.
  • Fever: lowering of elevated body temperature.
  • Dysmenorrhea: easing of menstrual cramps and associated pain.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which decreases the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin levels diminish inflammation, lower pain signaling, and reset the hypothalamic set‑point for body temperature, providing analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Heartburn: burning sensation in the chest or throat.
  • Dizziness: feeling light‑headed or unsteady.
  • Rash: mild skin irritation or itching.
  • Headache: new or worsening head pain.
  • Diarrhea: loose stools or increased bowel movements.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Renal impairment or acute kidney injury.
  • Severe allergic reactions such as anaphylaxis.
  • Liver enzyme elevation or hepatitis.
  • Cardiovascular thrombotic events including heart attack or stroke.
  • Blood disorders like thrombocytopenia.

Precautions & Warnings

Before using Ibuvalen, consider the following precautions:

  • Assess renal function: monitor in patients with kidney disease.
  • Avoid in active ulcer disease: risk of gastrointestinal bleeding.
  • Use with caution in asthma: may exacerbate bronchospasm.
  • Limit use in cardiovascular disease: increased risk of thrombotic events.
  • Avoid in pregnancy third trimester: potential fetal harm.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with several medicines; awareness helps minimize risk.

Major Interactions (Avoid)

  • Aspirin: increased risk of gastrointestinal bleeding.
  • Anticoagulants (warfarin, DOACs): heightened bleeding tendency.
  • Selective COX‑2 inhibitors: additive renal toxicity.
  • Lithium: elevated lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may diminish renal function.
  • Diuretics: potential for renal impairment.
  • Corticosteroids: increased risk of gastrointestinal ulceration.
  • SSRIs: elevated bleeding risk.
  • Alcohol: enhances gastrointestinal irritation and bleeding potential.

Frequently Asked Questions

Ibuvalen contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain such as headache, dental pain, musculoskeletal discomfort, and menstrual cramps, as well as to reduce fever and manage inflammatory conditions like osteoarthritis and rheumatoid arthritis.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels decrease inflammation, diminish pain signals, and help reset the body’s temperature regulation, providing analgesic, antipyretic, and anti‑inflammatory effects.

The appropriate dose of Ibuvalen is determined by a qualified prescriber based on the patient’s age, weight, medical condition and response to therapy. Patients should follow the prescribing information and never exceed the recommended amount without medical advice.

Ibuprofen is generally avoided in the third trimester of pregnancy because it may affect fetal cardiovascular development. Use during earlier stages or while breastfeeding should be discussed with a healthcare professional, who can weigh potential benefits against risks.

To place an order, submit an enquiry on the Ibuvalen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuvalen (ibuprofen) offers a balanced profile of analgesic, antipyretic and anti‑inflammatory activity, with a relatively short half‑life that allows flexible dosing. Compared with naproxen, it has a quicker onset but may require more frequent dosing; compared with aspirin, it provides stronger anti‑inflammatory effects with lower risk of gastric irritation at recommended doses.

Ibuvalen should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight and excessive heat to maintain stability and potency.

Ibuvalen is taken orally, usually with a full glass of water. It can be taken with or without food; however, taking it with food or milk may reduce the chance of stomach upset.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, renal impairment, liver injury, and increased cardiovascular events like heart attack or stroke, especially with high‑dose or prolonged use.

Ibuvalen should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, and during the third trimester of pregnancy. Patients with significant kidney or liver disease should consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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