Product image of Ibuver (Ibuprofen D,l-Lysinate) supplied by GNH India

Ibuver

Active Ingredient:
Ibuprofen D,l-Lysinate
Origin:
EU

Ibuver (Ibuprofen D,l-Lysinate)

Ibuprofen D,l-Lysinate, the active ingredient in Ibuver, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides analgesic, antipyretic, and anti‑inflammatory effects for adults and children when prescribed for appropriate conditions. It is indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory disorders.

GNH India supplies Ibuver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global logistics.

Manufacturer / TM Owner

Oy Verman Ab

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Indications & Clinical Uses

Ibuver, an NSAID, acts on the cyclooxygenase pathway to alleviate pain, fever, and inflammation.

  • Mild to moderate pain: Provides analgesic relief for headaches, dental pain, musculoskeletal aches, and menstrual discomfort.
  • Fever: Reduces elevated body temperature associated with infections or inflammatory processes.
  • Inflammatory conditions: Decreases swelling and discomfort in disorders such as osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen D,l-Lysinate non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce peripheral sensitization, fever generation, and inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

Ibuver may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or failure.
  • Severe hypersensitivity reactions, including Stevens‑Johnson syndrome.
  • Hepatic injury or elevated liver enzymes.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Anaphylaxis or angioedema.

Precautions & Warnings

When prescribing Ibuver, healthcare professionals should consider several safety measures.

  • Assess renal function: adjust use in patients with existing kidney disease.
  • Monitor gastrointestinal risk: avoid in individuals with a history of ulcer or bleeding.
  • Avoid concomitant anticoagulants: increased risk of hemorrhage.
  • Use with caution in asthma: NSAIDs may exacerbate bronchospasm.
  • Pregnancy and lactation: consult a healthcare provider before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Ibuver can interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • High‑dose aspirin: heightened renal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may reduce renal function when combined.
  • Diuretics: risk of electrolyte imbalance and reduced kidney perfusion.
  • Lithium: NSAIDs can raise serum lithium concentrations, requiring level checks.

Frequently Asked Questions

Ibuver contains ibuprofen D,l‑lysinate, an NSAID that is prescribed to relieve mild to moderate pain, lower fever, and reduce inflammation associated with conditions such as headaches, dental pain, musculoskeletal aches, and inflammatory joint disorders.

The lysinate salt of ibuprofen acts by non‑selectively inhibiting COX‑1 and COX‑2 enzymes, which decreases the synthesis of prostaglandins. Lower prostaglandin levels diminish peripheral pain signaling, suppress fever generation in the hypothalamus, and limit inflammatory exudate formation.

The appropriate dose of Ibuver is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Patients should follow the prescriber’s instructions and never adjust the dose on their own.

Safety of ibuprofen D,l‑lysinate in pregnancy or lactation has not been definitively established. It should only be used when the potential benefit outweighs the risk, and after consultation with a qualified healthcare provider.

To request Ibuver, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ibuver uses the lysinate salt of ibuprofen, which can improve aqueous solubility and may allow faster absorption compared with standard ibuprofen tablets. Therapeutic efficacy and safety profile remain comparable to other ibuprofen products when used at equivalent doses.

Store Ibuver at ambient temperature, preferably below 25 °C, in the original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiry date.

Ibuver is taken orally with a full glass of water. It may be taken with or without food; however, taking it with food can reduce the likelihood of gastrointestinal discomfort.

Serious risks include gastrointestinal ulceration or bleeding, acute kidney injury, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and cardiovascular events like myocardial infarction or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, blood in stool, sudden swelling, or difficulty breathing.

Ibuver should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, uncontrolled heart failure, and in the third trimester of pregnancy unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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