Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt presented as a sterile solution for extracorporeal use. It supplies calcium ions to support physiological processes and correct calcium deficiency in patients receiving intravenous fluids, dialysis or other extracorporeal therapies.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, dialysis centres and pharmacies worldwide, ensuring quality manufacturing, regulatory compliance, and reliable global distribution to meet clinical needs.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss, a calcium salt electrolyte, is employed in extracorporeal therapy pathways to maintain calcium balance.

  • Intravenous calcium supplementation: provides calcium ions in IV solutions to prevent hypocalcemia during fluid therapy.
  • Dialysis fluid additive: supplies calcium in dialysate to maintain electrolyte equilibrium during renal replacement therapy.
  • Extracorporeal circuit electrolyte replacement: restores calcium levels in cardiopulmonary bypass or other extracorporeal circulation systems.

How It Works

  • Calcium chloride dihydrate dissociates in solution to release calcium ions (Ca2+). The increased extracellular calcium concentration supports calcium‑dependent enzymatic reactions, muscle contraction, and coagulation pathways, while correcting hypocalcemia that can arise during intravenous fluid administration, dialysis, or extracorporeal circulation.

Side Effects

Adverse reactions may occur with calcium chloride dihydrate administration.

Common Side Effects

  • Local infusion site irritation: redness or discomfort at the injection site.
  • Transient hypercalcemia: temporary elevation of serum calcium levels.
  • Hypotension: drop in blood pressure during rapid infusion.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypercalcemia: can lead to cardiac arrhythmia or neuromuscular dysfunction.
  • Tissue calcification: deposition of calcium in soft tissues.
  • Allergic reaction or anaphylaxis: rare but potentially life‑threatening hypersensitivity.

Precautions & Warnings

When using Icalziss, consider the following safety measures.

  • Renal impairment: monitor serum calcium and adjust dose accordingly.
  • Cardiac disease: avoid rapid infusion rates to prevent arrhythmias.
  • Existing hypercalcemia: contraindicated, do not administer.
  • Concurrent calcium supplements: assess total calcium load to avoid excess.
  • Electrolyte monitoring: perform regular laboratory checks of calcium, magnesium, and phosphate.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride dihydrate may interact with other agents affecting calcium balance.

Major Interactions (Avoid)

  • Loop diuretics: increase renal calcium loss, risking hypocalcemia.
  • Vitamin D analogues (calcitriol): may precipitate severe hypercalcemia.
  • Bisphosphonates: can lower calcium levels, requiring careful monitoring.

Moderate Interactions (Monitor Closely)

  • Magnesium sulfate: alters calcium homeostasis, necessitate electrolyte checks.
  • Warfarin or other anticoagulants: calcium may affect clotting factor activity.
  • Other electrolytes (potassium, phosphate): simultaneous shifts require regular lab surveillance.

Frequently Asked Questions

Icalziss is a calcium chloride dihydrate solution used as a calcium source in intravenous fluids, as an additive in dialysis solutions, and for electrolyte replacement during extracorporeal therapies such as cardiopulmonary bypass.

When administered, calcium chloride dihydrate dissociates into calcium ions (Ca2+), raising extracellular calcium levels. This supports calcium‑dependent physiological processes, corrects hypocalcemia, and helps maintain electrolyte balance during fluid therapy and dialysis.

The dose of Icalziss is determined by the prescribing clinician based on the patient’s clinical condition, serum calcium levels, and the specific therapy (e.g., IV infusion or dialysis). Dosage is individualized and not standardized.

Safety data for calcium chloride dihydrate in pregnancy and lactation are limited. Use only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Icalziss, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Icalziss provides calcium in a highly soluble chloride form, allowing rapid increase of serum calcium levels, which is advantageous for intravenous and dialysis applications compared with calcium gluconate or calcium carbonate that are less soluble and typically used for oral supplementation.

Icalziss should be stored at ambient temperature, below 25 °C, in its original container. Protect the solution from moisture and direct sunlight. Ensure the container is sealed to maintain sterility until use.

Icalziss is administered intravenously or added to dialysis fluid by qualified healthcare personnel. The solution is infused into the bloodstream or mixed with dialysate according to the prescribed protocol and monitored for patient response.

The most serious risks include severe hypercalcemia, which can cause cardiac arrhythmias, neuromuscular dysfunction, and tissue calcification, as well as rare allergic reactions such as anaphylaxis. Continuous monitoring of serum calcium is essential during therapy.

Icalziss should not be used in patients with known hypercalcemia, severe renal impairment without monitoring, or those who have demonstrated hypersensitivity to calcium chloride. Clinicians should evaluate each patient’s condition before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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