Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium supplement presented as a sterile solution for extracorporeal use. It is employed to restore calcium levels and support cardiac and neuromuscular function in patients requiring electrolyte replenishment.\n\nGNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

  • Icalziss, a calcium supplement, acts on calcium homeostasis and electrolyte balance.\n\nHypocalcemia: restores serum calcium concentrations in patients with low calcium levels.\nCardiac arrest (calcium channel blockade): supports myocardial contractility during resuscitation.\nDialysis therapy: provides calcium during extracorporeal renal replacement procedures.\nHyperkalemia management: stabilises cardiac membranes when used alongside potassium‑lowering agents.

How It Works

  • Calcium chloride dihydrate dissociates to release calcium ions that increase extracellular calcium concentration. The elevated calcium enhances neuromuscular transmission, augments cardiac contractility, and participates in bone mineralisation pathways, thereby correcting electrolyte imbalances and supporting vital physiological functions.

Side Effects

  • Calcium chloride dihydrate may cause a range of adverse reactions when administered extracorporeally.\n\nCommon Side Effects:\n- Flushing or sensation of warmth at the infusion site.\n- Nausea or mild gastrointestinal discomfort.\n- Transient hypotension during rapid infusion.\n- Mild muscle cramps or tingling sensations.\n\nSerious or Rare Side Effects:\n- Severe hypercalcaemia leading to cardiac arrhythmias.\n- Tissue necrosis or ulceration if the solution extravasates.\n- Respiratory distress or bronchospasm.\n- Life‑threatening cardiac arrest in patients with underlying conduction disorders.

Precautions & Warnings

  • When using Icalziss, clinicians should observe several safety measures.\n\nAssess serum calcium: obtain baseline calcium levels before administration.\nMonitor cardiac rhythm: continuous ECG monitoring during infusion.\nCheck renal function: adjust dosing in patients with impaired kidney function.\nAvoid extravasation: ensure secure intravenous access and proper line placement.\nStore at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Calcium chloride dihydrate can interact with several medications, requiring careful management.\n\nMajor Interactions (Avoid):\n- Digitalis glycosides: increased risk of arrhythmia.\n- Loop diuretics: may exacerbate calcium loss.\n- Bisphosphonates: reduced therapeutic effect.\n- Magnesium sulfate: antagonistic effect on calcium activity.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors: monitor blood pressure for additive hypotensive effect.\n- Beta‑blockers: observe heart rate and contractility changes.

Frequently Asked Questions

Icalziss is a calcium chloride dihydrate solution used as an electrolyte replenisher. It is administered extracorporeally to correct low calcium levels, support cardiac contractility, and provide calcium during dialysis or other renal replacement therapies.

Calcium chloride dihydrate dissociates into calcium ions that raise extracellular calcium concentration. The increased calcium enhances neuromuscular transmission, improves myocardial contractility, and participates in bone mineralisation, thereby restoring normal physiological functions that depend on calcium.

The dose of Icalziss is determined by the prescribing clinician based on the patient’s serum calcium level, clinical condition, and the specific therapeutic context. Healthcare professionals calculate the appropriate amount and rate of infusion for each individual case.

Safety data for calcium chloride dihydrate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Icalziss, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Icalziss provides calcium in a highly soluble, injectable form suitable for extracorporeal administration, whereas oral calcium salts such as calcium carbonate are used for chronic supplementation. The injectable route allows rapid correction of severe hypocalcaemia and precise dosing during procedures like dialysis.

Icalziss should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the product from moisture and direct sunlight. Do not freeze the solution, and ensure the vial is kept upright to avoid leakage.

Icalziss is administered intravenously via an extracorporeal circuit or a dedicated IV line. The infusion rate and total volume are set by the treating clinician, who monitors the patient’s vital signs and serum calcium levels throughout the procedure.

The most serious risks include severe hypercalcaemia, which can cause cardiac arrhythmias or arrest, and tissue necrosis if the solution extravasates from the vein. Prompt recognition and immediate medical intervention are essential if these events occur.

Icalziss should be avoided in patients with known hypersensitivity to calcium chloride, uncontrolled hypercalcaemia, or severe cardiac conduction disorders unless closely monitored. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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