Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt (electrolyte supplement) presented as a sterile solution for extracorporeal use. It is employed to correct low serum calcium levels and to support electrolyte balance during dialysis and other extracorporeal procedures.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss is used as an electrolyte replenisher that restores calcium balance in several clinical situations.

  • Hypocalcemia: restores serum calcium concentrations in patients with documented low calcium levels.
  • Calcium supplementation during dialysis: provides calcium ions to maintain safe calcium levels throughout haemodialysis sessions.
  • Maintenance of electrolyte balance in extracorporeal circuits: stabilises calcium‑dependent processes in circuits such as continuous renal replacement therapy.
  • Cardiac contractility support in calcium‑deficient states: helps sustain myocardial contractile function when calcium is insufficient.

How It Works

  • Calcium chloride dihydrate dissociates in solution to release calcium ions (Ca²⁺). These ions are essential cofactors for neuromuscular transmission, cardiac muscle contraction, and the coagulation cascade. Intravenous administration rapidly raises extracellular calcium, thereby normalising serum calcium concentrations and supporting calcium‑dependent physiological processes.

Side Effects

Adverse reactions may occur with intravenous calcium administration.

Common Side Effects

  • Local irritation at the infusion site: redness or discomfort at the catheter entry.
  • Transient hypotension: temporary drop in blood pressure during rapid infusion.
  • Nausea or vomiting: gastrointestinal upset following administration.
  • Flushing or warmth sensation: mild vasodilatory response.
  • Muscle twitching: brief involuntary muscle activity.

Serious or Rare Side Effects

  • Severe hypercalcemia: excessive serum calcium leading to cardiac arrhythmia.
  • Cardiac arrhythmia: abnormal heart rhythm, potentially life‑threatening.
  • Vascular calcification: deposition of calcium in blood vessels with prolonged exposure.
  • Pulmonary edema: fluid accumulation in lungs due to rapid volume shifts.
  • Anaphylactoid reaction: rare severe allergic‑type response.

Precautions & Warnings

Careful assessment and monitoring are required when using Icalziss.

  • Renal impairment: monitor serum calcium and adjust infusion rate to avoid accumulation.
  • Cardiac disease: evaluate cardiac function before administration, especially in patients with arrhythmias.
  • Hyperparathyroidism: avoid unless calcium supplementation is specifically indicated.
  • Concomitant vitamin D therapy: assess total calcium load and modify dosing accordingly.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride may interact with several medications, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Digitalis glycosides: increased risk of digitalis toxicity due to altered calcium levels.
  • Loop diuretics: may enhance calcium loss, reducing the effectiveness of supplementation.
  • Bisphosphonates: calcium can bind to bisphosphonates, diminishing their absorption and efficacy.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: monitor blood pressure as calcium may influence vascular tone.
  • Beta‑blockers: observe for bradycardia when calcium alters cardiac conduction.
  • Antacids containing aluminum or magnesium: may affect calcium balance and require dose adjustment.

Frequently Asked Questions

Icalziss is an intravenous calcium chloride dihydrate solution used to correct low serum calcium levels, provide calcium during dialysis, and maintain electrolyte balance in extracorporeal circuits such as continuous renal replacement therapy.

When infused, calcium chloride dihydrate dissociates into calcium ions, which are vital for neuromuscular transmission, cardiac muscle contraction, and the blood‑clotting cascade. The added calcium quickly raises extracellular calcium, restoring normal physiological functions that depend on this electrolyte.

The dose of Icalziss is determined by the prescribing clinician based on the patient’s serum calcium level, clinical condition, and the specific procedure being performed. Healthcare professionals calculate the appropriate amount and infusion rate for each individual case.

Safety data for calcium chloride dihydrate in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by the treating physician. Breastfeeding mothers should consult their healthcare provider before receiving the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required), and necessary import documentation.

Icalziss provides calcium in a sterile, injectable form, allowing rapid correction of serum calcium. Oral calcium salts act more slowly and are unsuitable for immediate electrolyte replenishment during dialysis or extracorporeal therapies. Compared with calcium gluconate, calcium chloride delivers a higher elemental calcium concentration per millilitre, but may be more irritating to veins.

Icalziss should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly sealed and avoid freezing. Follow standard aseptic handling procedures when preparing the solution for infusion.

Icalziss is administered intravenously, typically through a central or peripheral line, as part of an extracorporeal circuit or during dialysis. The infusion rate and total volume are set by the clinician according to the patient’s calcium requirement and clinical status.

The most serious risks include severe hypercalcemia, which can cause cardiac arrhythmias, vascular calcification, and pulmonary edema. Rapid infusion may also lead to hypotension or anaphylactoid reactions. Continuous monitoring of serum calcium and cardiac function is essential during administration.

Icalziss should be avoided in patients with known hypersensitivity to calcium chloride, uncontrolled hypercalcemia, severe renal failure without appropriate monitoring, and in those with conditions where rapid calcium shifts could be harmful, such as certain types of cardiac block or severe heart failure, unless specifically indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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