Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium Chloride Dihydrate, the active ingredient in Icalziss, is a mineral salt presented as an extracorporeal use product for calcium supplementation in clinical settings. It is employed to correct low calcium levels during procedures such as dialysis or cardiac surgery.
GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss provides calcium ions for extracorporeal therapies and is used in the following clinical situations:

  • Dialysis‑associated hypocalcemia: restores serum calcium to target ranges during renal replacement therapy.
  • Cardiopulmonary bypass: supplies calcium to support myocardial contractility and vascular tone.
  • Acute calcium depletion: corrects rapid drops in calcium during massive transfusion or citrate toxicity.

How It Works

  • Calcium Chloride Dihydrate dissociates in solution to release calcium ions (Ca2+). The free calcium participates in numerous physiological processes, including activation of calcium‑dependent enzymes, stabilization of cell membranes, and facilitation of coagulation cascade steps. In extracorporeal circuits, the added calcium counteracts citrate binding and helps maintain normal electrophysiological and contractile functions.

Side Effects

Icalziss may be associated with a range of adverse reactions, most of which are related to excess calcium exposure.

Common Side Effects

  • Hypercalcemia: elevated serum calcium levels.
  • Hypotension: vasodilation due to calcium‑mediated vascular effects.
  • Nausea or vomiting.
  • Local irritation at infusion site.
  • Muscle weakness or cramps.

Serious or Rare Side Effects

  • Cardiac arrhythmias: especially in patients with underlying heart disease.
  • Calcification of tissues: prolonged high calcium concentrations.
  • Metabolic alkalosis: secondary to chloride load.
  • Severe hypotension leading to shock.
  • Renal impairment exacerbation.

Precautions & Warnings

When using Icalziss, consider the following safety measures:

  • Serum calcium monitoring: check levels before, during, and after administration.
  • Cardiac monitoring: observe for arrhythmias, especially in patients with cardiac disease.
  • Renal function assessment: adjust use in patients with impaired kidney function.
  • Avoid in hypercalcemia: contraindicated when serum calcium is already elevated.
  • Compatibility check: ensure the solution is compatible with other intravenous fluids.
  • Store at ambient temperature: keep below 25°C, protect from moisture and direct sunlight.

Avoid Interactions

Icalziss can interact with other agents that affect calcium balance or cardiac conduction.

Major Interactions (Avoid)

  • Calcium channel blockers: may blunt therapeutic calcium effects and increase risk of hypotension.
  • Digoxin: excess calcium can potentiate digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase calcium excretion, requiring closer monitoring of serum levels.
  • Magnesium sulfate: concurrent high magnesium may exacerbate cardiac conduction disturbances.
  • Citrate‑containing blood products: may require dose adjustment to avoid calcium overload.

Frequently Asked Questions

Icalziss is used to provide calcium ions during extracorporeal medical procedures such as dialysis, cardiopulmonary bypass, and situations of acute calcium depletion. It helps restore normal calcium levels and supports cardiac and vascular function.

Calcium Chloride Dihydrate dissociates into calcium and chloride ions. The calcium ions participate in enzymatic reactions, stabilize cell membranes, and are essential for muscle contraction and blood clotting, thereby correcting low calcium states during extracorporeal therapy.

The dose of Icalziss is determined by the prescribing clinician based on the patient’s serum calcium level, the type of procedure, and individual clinical factors. Dosage instructions are provided on the prescription label.

Safety of Icalziss in pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Icalziss, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Icalziss delivers calcium as calcium chloride, which provides a rapid increase in ionized calcium compared with calcium gluconate or calcium carbonate. It is preferred in extracorporeal settings where immediate calcium correction is needed, whereas oral supplements are used for chronic management.

Icalziss should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain stability.

Icalziss is administered intravenously as part of an extracorporeal circuit. The solution is added to the fluid line under controlled conditions, with dosing adjusted according to real‑time calcium monitoring.

The most serious risks include severe hypercalcemia, cardiac arrhythmias, and tissue calcification. Prompt monitoring of serum calcium and cardiac rhythm is essential to detect and manage these complications early.

Icalziss should not be used in patients with known hypercalcemia, severe renal impairment without appropriate monitoring, or in those receiving medications that could cause dangerous calcium‑related interactions, such as certain digoxin regimens.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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