Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a mineral salt presented as an unspecified strength sterile solution for extracorporeal use. It supplies calcium ions in medical procedures involving external circuits, such as dialysis or organ perfusion.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss provides calcium ions for extracorporeal medical procedures and supports calcium balance in specialized fluid systems.

  • Dialysis solutions: restores calcium levels in patients undergoing hemodialysis.
  • Organ preservation solutions: maintains calcium homeostasis during extracorporeal organ perfusion.
  • Blood component processing: used in anticoagulant or additive solutions for extracorporeal circuits.

How It Works

  • Calcium chloride dihydrate dissociates in solution to release calcium ions (Ca²⁺) and chloride ions. The free calcium ions act as essential cofactors in enzymatic reactions, stabilize cell membranes, and participate in coagulation cascades. In extracorporeal circuits, the added calcium helps maintain physiological calcium concentrations, supporting normal cellular function and preventing hypocalcemia during procedures such as dialysis or organ perfusion.

Side Effects

Calcium chloride dihydrate can cause a range of reactions when administered extracorporeally.

Common Side Effects

  • Local irritation at infusion site: mild redness or discomfort.
  • Transient hypercalcemia: temporary elevation of serum calcium levels.
  • Hypotension: mild drop in blood pressure during rapid infusion.
  • Nausea: occasional feeling of queasiness.
  • Muscle cramps: brief involuntary muscle tightening.

Serious or Rare Side Effects

  • Severe hypercalcemia: may lead to cardiac arrhythmias.
  • Tissue necrosis: if the solution extravasates into surrounding tissue.
  • Cardiac arrest: extremely rare, associated with massive calcium overload.
  • Allergic reaction: rash, itching, or anaphylaxis in hypersensitive individuals.
  • Metabolic alkalosis: due to chloride shift in large volumes.

Precautions & Warnings

When using Icalziss, consider the following safety measures.

  • Dose verification: ensure prescribed calcium concentration matches patient needs.
  • Monitoring: regularly check serum calcium and electrolytes during therapy.
  • Infusion rate: administer slowly to avoid rapid calcium spikes.
  • Compatibility: confirm compatibility with other solutions in the circuit.
  • Patient history: assess for pre‑existing hypercalcemia or cardiac disease.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride may interact with several agents; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Calcium channel blockers: additive cardiovascular effects may cause hypotension.
  • Digoxin: increased calcium can potentiate digoxin toxicity.
  • Loop diuretics: may exacerbate calcium loss leading to imbalance.

Moderate Interactions (Monitor Closely)

  • Vitamin D supplements: can amplify calcium levels, requiring monitoring.
  • Bisphosphonates: calcium may reduce drug absorption if given concurrently.
  • Magnesium sulfate: antagonistic effect on calcium signaling pathways.

Frequently Asked Questions

Icalziss contains calcium chloride dihydrate and is used to provide calcium ions in extracorporeal medical procedures such as hemodialysis, organ perfusion, and blood component processing. It helps maintain calcium balance in specialized fluid systems.

When dissolved, calcium chloride dihydrate releases calcium (Ca²⁺) and chloride ions. The calcium ions act as essential cofactors in many physiological processes, stabilizing cell membranes and supporting enzymatic reactions, thereby correcting calcium deficits in extracorporeal circuits.

The dose of Icalziss is determined by the prescribing clinician based on the specific procedure, patient’s serum calcium level, and the composition of the extracorporeal circuit. No fixed regimen is provided here.

Safety of calcium chloride dihydrate in pregnancy or lactation has not been fully established. Use only if the potential benefit justifies any potential risk, and discuss with a qualified healthcare professional.

To order Icalziss, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Icalziss is formulated for extracorporeal use, delivering calcium in a sterile solution suitable for dialysis or organ perfusion. Conventional oral calcium supplements are intended for systemic ingestion and are not appropriate for use in external circuits.

Store Icalziss at ambient temperature, below 25 °C, in its original packaging. Protect the container from moisture, direct sunlight, and extreme temperature fluctuations to maintain solution stability.

Icalziss is added to the extracorporeal circuit according to the prescriber's instructions. It is typically infused into dialysis fluid, organ preservation solutions, or blood processing systems under controlled conditions.

Serious risks include severe hypercalcemia, which can cause cardiac arrhythmias or arrest, and tissue necrosis if the solution leaks into surrounding tissue. Continuous monitoring of serum calcium and careful infusion techniques are essential.

Patients with known hypersensitivity to calcium chloride, uncontrolled hypercalcemia, severe cardiac disease, or those receiving incompatible medications should not receive Icalziss unless a specialist determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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