Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt presented as an unspecified strength and form for extracorporeal use. It helps restore extracellular calcium levels in patients with hypocalcemia, supports cardiac stability during hyperkalemic emergencies, and provides essential calcium during dialysis or massive transfusion procedures in clinical settings.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vantive Belgium

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Icalziss is used as an electrolyte replenisher to correct calcium deficits in several clinical situations.

  • Hypocalcemia: restores serum calcium concentrations to normal levels.
  • Hyperkalemic cardiac arrest: stabilizes myocardial cell membranes and reduces arrhythmic risk.
  • Massive transfusion protocols: supplies calcium ions lost during citrate anticoagulation of blood products.
  • Renal replacement therapy: corrects calcium balance during dialysis procedures.

How It Works

  • Calcium chloride dihydrate dissociates in solution to release calcium (Ca²⁺) and chloride ions. The liberated Ca²⁺ raises extracellular calcium concentration, which is essential for myocardial contractility, vascular tone, and activation of the coagulation cascade. By increasing serum calcium, the drug counteracts the membrane‑stabilizing effects of hyperkalemia, supports enzymatic processes, and replenishes calcium lost through citrate binding or renal excretion.

Side Effects

Calcium chloride dihydrate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Infusion site irritation or pain
  • Transient hypotension or flushing
  • Nausea or vomiting
  • Metallic taste in the mouth
  • Headache or dizziness

Serious or Rare Side Effects

  • Hypercalcemia leading to cardiac arrhythmias
  • Severe hypotension or cardiovascular collapse
  • Tissue necrosis at extravasation sites
  • Anaphylactic or severe allergic reactions
  • Cardiac arrest in the setting of rapid administration

Precautions & Warnings

When using Icalziss, clinicians should observe several safety measures to minimize risks.

  • Monitor serum calcium: check levels before and during therapy.
  • Assess cardiac function: continuous ECG monitoring is recommended.
  • Use caution in renal impairment: adjust dose as needed.
  • Avoid rapid infusion: administer over the recommended time to prevent hypotension.
  • Review concomitant digoxin therapy: calcium may increase digoxin toxicity.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride dihydrate can interact with several medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Digoxin: increased risk of arrhythmias.
  • Calcium channel blockers: enhanced hypotensive effect.
  • Loop diuretics: altered calcium excretion may cause imbalance.
  • Bicarbonate solutions: precipitation of calcium carbonate.
  • Blood products containing citrate: excess calcium may cause hypercalcemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible additive blood pressure effects.
  • Beta‑blockers: monitor for bradycardia.
  • Antacids containing aluminum or magnesium: may affect calcium absorption.
  • Phosphate binders: potential calcium‑phosphate precipitation.
  • Magnesium supplements: monitor combined electrolyte levels.

Frequently Asked Questions

Icalziss is a calcium chloride dihydrate preparation used as an electrolyte replenisher. It is employed to correct low calcium levels (hypocalcemia), to stabilize the heart during hyperkalemic cardiac events, to provide calcium during massive transfusion protocols, and to maintain calcium balance in patients undergoing dialysis.

The compound dissociates in solution, releasing calcium ions (Ca²⁺). These ions increase extracellular calcium concentration, which is vital for muscle contraction, nerve transmission, blood clotting, and stabilising cardiac cell membranes, especially when high potassium levels threaten heart rhythm.

The appropriate dose of Icalziss is determined by the prescribing clinician based on the patient’s clinical condition, serum calcium level, and the intended therapeutic use. Dosing is individualized and should follow the healthcare professional’s instructions.

Safety data for calcium chloride dihydrate in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Icalziss product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Icalziss provides calcium in the form of calcium chloride dihydrate, which delivers calcium ions rapidly when administered extracorporeally. Compared with oral calcium salts such as calcium carbonate, it is used in acute clinical settings where immediate correction of calcium levels is required, rather than for long‑term oral supplementation.

Icalziss should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly sealed to maintain stability.

Icalziss is administered via an extracorporeal route, typically as an intravenous infusion. The exact method, infusion rate and dilution are determined by the treating clinician and should follow institutional protocols for calcium replacement therapy.

The most serious risks include hypercalcemia, which can cause cardiac arrhythmias or cardiac arrest, severe hypotension, tissue necrosis if the solution extravasates, and rare but severe allergic reactions such as anaphylaxis. Prompt monitoring during administration helps detect these events early.

Icalziss should be avoided in patients with known hypersensitivity to calcium chloride, in those with severe hypercalcemia, and in individuals where rapid calcium infusion could exacerbate existing cardiac conditions unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Calcium Chloride Dihydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT