Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt / electrolyte presented as a solution for injection for extracorporeal use. It treats hypocalcemia, provides calcium supplementation during extracorporeal procedures, and supports cardiac contractility and vascular tone in acute care patients.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss is used to correct calcium deficits and to support cardiovascular function in settings where calcium balance is critical.

  • Hypocalcemia: restores extracellular calcium levels to correct low serum calcium.
  • Citrate anticoagulation reversal during extracorporeal procedures: supplies calcium ions to counteract citrate‑bound calcium.
  • Acute cardiac and vascular support: enhances myocardial contractility and vascular tone in emergency or intensive care situations.

How It Works

  • Calcium chloride dihydrate dissociates after injection, releasing calcium ions that raise extracellular calcium concentration. Elevated calcium enhances myocardial contractility, stabilises vascular smooth‑muscle tone, and provides essential cofactors for the coagulation cascade, thereby supporting cardiac output, blood pressure regulation, and hemostasis during acute care or extracorporeal therapies.

Side Effects

Adverse reactions may occur following administration of calcium chloride injection.

Common Side Effects

  • Injection site pain or irritation.
  • Redness or swelling at the infusion site.
  • Nausea or vomiting.
  • Headache.
  • Transient hypotension.
  • Mild hypercalcemia symptoms such as fatigue.

Serious or Rare Side Effects

  • Severe hypercalcemia leading to cardiac arrhythmias.
  • Tissue necrosis if the solution extravasates.
  • Cardiac arrest.
  • Severe hypotension.
  • Anaphylactic or severe allergic reactions.
  • Pulmonary edema.

Precautions & Warnings

Careful assessment and monitoring are required when using Icalziss.

  • Renal impairment: monitor serum calcium and renal function closely.
  • Cardiac disease: use cautiously due to potential effects on contractility and rhythm.
  • Existing hypercalcemia: avoid or adjust dose to prevent toxicity.
  • Concomitant anticoagulants: monitor coagulation parameters for unexpected changes.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Calcium chloride may interact with several medications, requiring vigilance.

Major Interactions (Avoid)

  • Digitalis glycosides: increased risk of arrhythmia due to elevated calcium levels.
  • Bisphosphonates: calcium may reduce the efficacy of bisphosphonate therapy.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase calcium excretion; monitor serum calcium.
  • Anticoagulants (e.g., heparin): calcium can influence coagulation; observe clotting times.
  • Calcium channel blockers: potential attenuation of calcium’s cardiovascular effects; assess hemodynamics.

Frequently Asked Questions

Icalziss is an injectable solution of calcium chloride dihydrate used to correct low blood calcium levels (hypocalcemia), to reverse citrate anticoagulation during extracorporeal procedures, and to support cardiac contractility and vascular tone in acute care settings.

After injection, calcium chloride dihydrate dissociates into calcium ions, raising extracellular calcium concentration. This increase enhances myocardial contractility, stabilises vascular smooth‑muscle tone, and provides essential cofactors for the coagulation cascade, thereby supporting heart function, blood pressure, and clot formation.

The dose of Icalziss is determined by the prescribing clinician based on the patient’s serum calcium level, clinical condition, and the specific procedure being performed. Healthcare professionals calculate the appropriate amount and rate of administration for each individual case.

Safety data for calcium chloride dihydrate in pregnancy and lactation are limited. The product should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Icalziss, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and necessary import documentation.

Icalziss provides calcium chloride dihydrate, which delivers calcium ions rapidly and is especially useful for urgent correction of hypocalcemia or citrate anticoagulation reversal. Compared with calcium gluconate, calcium chloride contains a higher elemental calcium concentration, allowing smaller volumes for the same effect, but it may be more irritating to veins.

Icalziss should be stored at 2‑8 °C, protected from light, and must not be frozen. Keep the vial in its original packaging, avoid shaking the solution, and inspect for particulate matter before use. Follow standard aseptic techniques during preparation and administration.

Icalziss is administered intravenously by a qualified healthcare professional. The solution is typically diluted in compatible IV fluids and infused at a controlled rate, depending on the clinical indication and patient response. Administration should follow institutional protocols and monitor the patient for signs of calcium imbalance.

Serious risks include severe hypercalcemia, which can cause cardiac arrhythmias, cardiac arrest, or tissue necrosis if the solution extravasates. Rapid infusion may also lead to hypotension or pulmonary edema. Immediate medical attention is required if any severe adverse reaction is suspected.

Icalziss should be avoided in patients with known hypercalcemia, severe renal impairment, uncontrolled cardiac arrhythmias, or those who have had a severe allergic reaction to calcium chloride. Contraindications must be evaluated by the prescribing clinician before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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