Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is an electrolyte supplement presented as a solution for extracorporeal use. It provides calcium ions to support electrolyte balance and physiological functions in patients requiring intravenous calcium replacement.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to strict quality standards and provides regulatory documentation for importers and health‑care institutions across multiple regions. Products are shipped under controlled conditions to ensure stability and compliance with EU pharmacopeial specifications.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss (calcium chloride dihydrate) is used to restore calcium levels in clinical situations involving electrolyte imbalance.

  • Hypocalcemia: restores serum calcium concentrations in patients with acute or chronic low calcium levels.
  • Parenteral nutrition: supplies calcium as an essential mineral in total parenteral nutrition admixtures.
  • Hemodialysis: provides calcium in dialysis solutions to maintain calcium balance during extracorporeal treatment.
  • Cardiac arrest support: delivers calcium ions during resuscitation to assist myocardial contractility.

How It Works

  • Calcium chloride dihydrate dissociates in aqueous solution to release calcium ions (Ca2+). The free calcium increases extracellular calcium concentration, which is readily taken up by cells and contributes to the activation of calcium‑dependent enzymes, muscle contraction, neurotransmission, and blood coagulation cascades. In intravenous applications the rapid rise in serum calcium corrects deficits and supports physiological processes that rely on calcium signaling.

Side Effects

Calcium chloride dihydrate may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects

  • Irritation at infusion site: redness, pain, or swelling where the solution is administered.
  • Hypercalcemia: transient elevation of serum calcium causing mild nausea or fatigue.
  • Nausea or vomiting: gastrointestinal discomfort following rapid infusion.
  • Hypotension: drop in blood pressure during or shortly after administration.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythms, especially in patients with underlying heart disease.
  • Severe hypercalcemia: can lead to confusion, renal impairment, or calcification of tissues.
  • Tissue necrosis: extravasation of the solution may cause local tissue damage.
  • Anaphylactic reaction: rare severe allergic response requiring immediate medical intervention.

Precautions & Warnings

When using Icalziss, several precautions should be observed to minimize risks and ensure safe administration.

  • Monitor serum calcium: check calcium levels before, during, and after infusion to avoid over‑correction.
  • Assess renal function: impaired kidneys may reduce calcium clearance and increase toxicity risk.
  • Infuse slowly: rapid administration can cause cardiovascular instability and local irritation.
  • Review cardiac history: patients with arrhythmias or myocardial ischemia require careful monitoring.
  • Check compatibility: ensure the solution is compatible with other IV fluids and medications before mixing.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride dihydrate can interact with certain medicines, affecting their efficacy or safety.

Major Interactions (Avoid)

  • Bisphosphonates: concurrent IV calcium may reduce the anti‑resorptive effect of bisphosphonates.
  • Calcium channel blockers: high calcium levels can diminish the hypotensive action of these agents.
  • Potassium chloride solutions: mixing can cause precipitation and catheter blockage.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase calcium excretion, requiring closer monitoring of calcium levels.
  • Digitalis glycosides: elevated calcium may enhance digitalis toxicity.
  • Magnesium sulfate: concurrent administration can lead to electrolyte imbalance; monitor both ions.
  • Phosphate binders: calcium may bind phosphate, altering phosphate control in renal patients.

Frequently Asked Questions

Icalziss contains calcium chloride dihydrate and is employed to correct low calcium levels, provide calcium in total parenteral nutrition admixtures, and maintain calcium balance in dialysis or other extracorporeal therapies. It serves as an intravenous source of calcium ions for patients who need rapid electrolyte correction.

When dissolved, calcium chloride dihydrate releases calcium ions (Ca2+) into the bloodstream. The increased extracellular calcium is taken up by cells, supporting muscle contraction, nerve transmission, blood clotting, and enzyme activation. This rapid rise in serum calcium helps reverse hypocalcemia and supports physiological processes dependent on calcium signaling.

The dose of Icalziss is individualized and determined by the prescribing clinician based on the patient’s serum calcium level, underlying condition, and overall clinical status. Healthcare professionals calculate the appropriate volume and rate of infusion to safely correct calcium deficits without causing over‑correction.

Limited clinical data are available on the use of calcium chloride dihydrate in pregnant or lactating women. The decision to use Icalziss during pregnancy or while breastfeeding should be made by a qualified healthcare provider, weighing potential benefits against any possible risks to the mother and fetus or infant.

To order Icalziss, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Icalziss provides calcium as calcium chloride, which releases calcium ions more rapidly than calcium gluconate or calcium carbonate. This makes it suitable for acute correction of hypocalcemia or use in dialysis solutions. However, the faster rise in serum calcium can increase the risk of hypercalcemia, so careful monitoring is essential.

Icalziss should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations. Follow any manufacturer‑provided handling instructions to maintain solution stability before use.

Icalziss is administered intravenously as an extracorporeal solution. It is typically infused through a controlled IV line or dialysis circuit, with the rate and volume determined by the prescribing clinician to achieve the desired correction of calcium levels while minimizing adverse effects.

Serious risks include cardiac arrhythmias, severe hypercalcemia leading to neurological or renal complications, tissue necrosis from extravasation, and rare anaphylactic reactions. Prompt recognition of symptoms such as irregular heart rhythm, confusion, severe muscle weakness, or allergic signs is critical for immediate medical intervention.

Icalziss should be avoided in patients with known hypersensitivity to calcium chloride, severe hypercalcemia, uncontrolled cardiac arrhythmias, or those for whom rapid calcium infusion is contraindicated. Clinicians should also exercise caution in individuals with impaired renal function or severe heart disease, adjusting therapy as needed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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