Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium supplement/electrolyte presented as a sterile solution for extracorporeal use. It provides calcium ions to maintain extracellular calcium concentration and supports calcium balance during dialysis, plasma exchange, and cardiac surgery procedures.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss is employed to correct calcium deficits and maintain electrolyte balance in clinical situations that involve extracorporeal circulation.

  • Hemodialysis: restores calcium levels to prevent hypocalcemia during the treatment.
  • Plasma exchange: supplies calcium ions to maintain coagulation and electrolyte homeostasis.
  • Cardiac surgery with cardiopulmonary bypass: stabilizes calcium concentration to support myocardial function.
  • Hyperparathyroidism postoperative management: provides controlled calcium replacement when rapid shifts occur.

How It Works

  • Calcium chloride dihydrate dissociates in solution to release calcium (Ca2+) and chloride ions. The free calcium ions increase extracellular calcium concentration, which is essential for myocardial contractility, vascular tone, and the activation of the coagulation cascade. By augmenting ionized calcium, the product helps correct hypocalcemia that can arise during extracorporeal procedures such as dialysis, plasma exchange, or cardiopulmonary bypass in the patient.

Side Effects

Calcium chloride dihydrate may be associated with several adverse reactions, most of which are related to rapid changes in serum calcium levels.

Common Side Effects

  • Transient hypercalcemia: temporary elevation of serum calcium that usually resolves after infusion.
  • Local infusion site irritation: redness or discomfort at the catheter entry point.
  • Mild hypotension: slight drop in blood pressure during rapid administration.
  • Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects

  • Severe hypercalcemia: marked elevation of calcium that can cause cardiac arrhythmias.
  • Cardiac arrhythmias: irregular heart rhythms, including ventricular tachycardia.
  • Vascular calcification: deposition of calcium in blood vessels with prolonged exposure.
  • Anaphylactic reaction: rare severe allergic response requiring immediate treatment.

Precautions & Warnings

When using Icalziss, careful clinical monitoring and appropriate patient selection are essential to minimize risks.

  • Baseline calcium assessment: measure serum ionized calcium before initiating therapy.
  • Continuous monitoring: check calcium levels and cardiac rhythm during infusion.
  • Renal impairment adjustment: reduce dose or extend infusion time in patients with reduced kidney function.
  • Hypercalcemia avoidance: do not administer to patients with existing elevated calcium levels.
  • Concomitant digitalis caution: monitor for enhanced cardiac effects when used with digoxin.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride dihydrate can affect the activity of several medicines, requiring attention to potential interactions.

Major Interactions (Avoid)

  • Calcium channel blockers: may potentiate hypotensive effects.
  • Bisphosphonates: calcium can reduce absorption and efficacy of bisphosphonate therapy.
  • High‑dose vitamin D: combined use may precipitate severe hypercalcemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal calcium loss, necessitating closer calcium monitoring.
  • Magnesium sulfate: concurrent administration can alter calcium balance and require dose adjustments.

Frequently Asked Questions

Icalziss is a sterile calcium chloride dihydrate solution used to replace calcium and maintain electrolyte balance during extracorporeal procedures such as hemodialysis, plasma exchange, and cardiopulmonary bypass. It helps prevent hypocalcemia that can arise when calcium is removed from the blood circuit.

When dissolved, calcium chloride dihydrate releases calcium (Ca2+) and chloride ions. The calcium ions raise the extracellular calcium concentration, supporting myocardial contractility, vascular tone, and the activation of clotting factors. This rapid increase corrects low calcium levels that may develop during extracorporeal treatments.

The dose of Icalziss is individualized by the prescribing clinician based on the patient’s baseline serum calcium, the type of extracorporeal procedure, and the rate of calcium loss during treatment. No fixed regimen is provided; the healthcare professional calculates the appropriate amount and infusion rate.

Safety data for calcium chloride dihydrate in pregnant or lactating women are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Icalziss, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike oral calcium tablets or chewable supplements, Icalziss is a sterile injectable solution designed for direct addition to extracorporeal circuits. This allows rapid correction of calcium levels during procedures, whereas oral products act more slowly and are not suitable for use in dialysis or plasma‑exchange settings.

Icalziss should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight and extreme temperature fluctuations. Do not freeze; inspect the vial for particulate matter before use.

Icalziss is added to the extracorporeal circuit or dialysis machine as a sterile solution. The infusion rate is controlled by the equipment and adjusted by the clinical team according to the patient’s serum calcium measurements and the specific procedure being performed.

The most serious adverse events include severe hypercalcemia, which can lead to cardiac arrhythmias, vascular calcification with prolonged exposure, and rare anaphylactic reactions. Continuous monitoring of ionized calcium and cardiac rhythm is essential to detect these complications early.

Icalziss should be avoided in patients with known hypercalcemia, severe renal impairment where calcium clearance is markedly reduced, or a documented hypersensitivity to calcium chloride. Clinicians should also exercise caution in individuals receiving high‑dose vitamin D or other calcium‑raising therapies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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