Product image of Icalziss (Calcium Chloride Dihydrate) supplied by GNH India

Icalziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icalziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt presented as a sterile solution for extracorporeal use. It helps restore extracellular calcium concentrations in patients with hypocalcemia or calcium deficiency, particularly in settings such as dialysis or surgery. It is indicated for rapid correction of calcium deficits and is compatible with standard dialysis circuits.

GNH India supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide, adhering to EU quality standards and providing reliable logistics for clinical and institutional customers.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icalziss is used as an electrolyte replenisher to address conditions associated with low calcium levels.

  • Hypocalcemia: rapid increase of serum calcium to normal range.
  • Calcium deficiency: replenishment of extracellular calcium during dialysis or prolonged fasting.
  • Peri‑operative calcium management: maintenance of calcium homeostasis during surgical procedures.

How It Works

  • Calcium chloride dihydrate dissociates in solution to release calcium ions (Ca2+). The free calcium increases extracellular calcium concentration, which is taken up by cells and binds to plasma proteins, thereby correcting hypocalcemia. The rise in ionized calcium restores normal cardiac, neuromuscular and coagulation functions and supports calcium‑dependent enzymatic processes. Additionally, the elevated calcium modulates voltage‑gated channels and stabilizes cell membranes, contributing to improved physiological stability during therapeutic interventions.

Side Effects

Calcium chloride administration may be associated with adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hypercalcemia: transient elevation of serum calcium causing mild symptoms.
  • Hypotension: drop in blood pressure during rapid infusion.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Muscle cramps or tingling: neuromuscular irritation.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm due to calcium overload.
  • Tissue necrosis: severe local injury if the solution extravasates.
  • Anaphylactic reaction: rare severe allergic response.

Precautions & Warnings

When using Icalziss, clinicians should observe specific safety measures.

  • Monitor serum calcium: check levels before, during, and after infusion.
  • Adjust infusion rate: avoid rapid bolus to reduce cardiovascular stress.
  • Contraindicated in severe hypercalcemia: do not administer when calcium is already elevated.
  • Use with caution in renal impairment: altered calcium handling may require dose modification.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Calcium chloride can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Digoxin: increased risk of arrhythmia due to altered calcium homeostasis.
  • Loop diuretics: enhanced calcium loss may counteract therapeutic effect.
  • Bisphosphonates: additive calcium load can precipitate hypercalcemia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: reduced calcium excretion may raise serum levels.
  • Vitamin D analogs: synergistic increase in calcium absorption.
  • Calcium‑containing antacids: cumulative calcium effect may require monitoring.

Frequently Asked Questions

Icalziss is an electrolyte replenisher containing calcium chloride dihydrate. It is used to correct low calcium levels (hypocalcemia) and treat calcium deficiency, especially in patients undergoing dialysis or those who require rapid restoration of extracellular calcium.

The calcium chloride dihydrate in Icalziss dissociates to release calcium ions (Ca2+). These ions raise extracellular calcium concentrations, supporting cardiac, neuromuscular and coagulation functions and helping restore normal physiological processes that depend on calcium.

The dose of Icalziss is determined by the prescribing clinician based on the patient’s serum calcium level, clinical condition, and the intended route of administration. Specific dosing regimens are not provided here and should follow the prescriber’s instructions.

Safety data for Icalziss in pregnancy or lactation are limited. Use only if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made by the treating physician in consultation with the patient.

To order Icalziss, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Icalziss provides calcium chloride dihydrate, which delivers calcium ions more rapidly than calcium gluconate or calcium carbonate. This makes it suitable for acute correction of calcium deficits, whereas other salts may be used for slower, oral supplementation or for patients with different tolerance profiles.

Store Icalziss at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is sealed when not in use.

Icalziss is supplied as a sterile solution for extracorporeal administration, typically infused into a dialysis circuit or administered intravenously under controlled conditions. The exact method and rate are determined by the healthcare professional based on the clinical scenario.

Serious risks include cardiac arrhythmias, severe hypercalcemia, tissue necrosis if the solution extravasates, and rare anaphylactic reactions. Continuous monitoring of serum calcium and cardiovascular status is essential during and after administration.

Icalziss should not be given to patients with known severe hypercalcemia, uncontrolled cardiac arrhythmias, or hypersensitivity to calcium chloride. Clinicians should also exercise caution in patients with renal impairment or those receiving interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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