Product image of Icatibant Aguettant (Icatibant) supplied by GNH India

Icatibant Aguettant

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Aguettant (Icatibant)

Icatibant, the active ingredient in Icatibant Aguettant, is a bradykinin B2 receptor antagonist presented as a solution for injection for subcutaneous use. It treats hereditary angioedema caused by C1 inhibitor deficiency in patients requiring acute attack management.

GNH India supplies Icatibant Aguettant as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Icatibant acts on the bradykinin pathway to relieve swelling in hereditary angioedema.

  • Hereditary angioedema (C1‑INH deficiency): provides rapid reduction of edema during acute attacks.
  • Acute hereditary angioedema attacks: alleviates symptoms within minutes of administration.
  • Hereditary angioedema types I and II: effective in both subtypes for emergency treatment.

How It Works

  • Icatibant selectively antagonizes the bradykinin B2 receptor, blocking bradykinin‑induced vasodilation and increased vascular permeability. By preventing this receptor activation, it reduces the fluid extravasation that leads to the swelling characteristic of hereditary angioedema attacks.

Side Effects

Icatibant may cause a range of adverse reactions following subcutaneous injection.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or erythema: localized skin redness.
  • Swelling at injection site: transient local edema.
  • Nausea: occasional gastrointestinal upset.
  • Headache: mild to moderate intensity.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Hypersensitivity reactions: rash, urticaria, or anaphylaxis.
  • Severe hypotension: sudden drop in blood pressure.
  • Angioedema of the face or throat: may compromise airway.
  • Infection at injection site: signs of cellulitis.
  • Thrombocytopenia: reduced platelet count.
  • Cardiovascular events: rare cardiac complications.

Precautions & Warnings

When prescribing Icatibant, clinicians should consider several safety aspects.

  • Renal impairment: monitor renal function and adjust use if needed.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Concomitant ACE inhibitors: may reduce therapeutic effect.
  • Known hypersensitivity: contraindicated in patients with allergy to icatibant or excipients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant can interact with other medicines that affect the bradykinin system or cardiovascular parameters.

Major Interactions (Avoid)

  • ACE inhibitors: may diminish icatibant efficacy.
  • Angiotensin receptor blockers: similar potential reduction in effect.
  • C1‑inhibitor concentrate: concurrent use not recommended.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor blood pressure for additive hypotensive effects.
  • Other bradykinin pathway modulators: assess for overlapping actions.
  • Antihistamines: may mask early signs of hypersensitivity.

Frequently Asked Questions

Icatibant Aguettant is indicated for the acute treatment of hereditary angioedema attacks caused by C1‑inhibitor deficiency. It provides rapid relief of swelling and related symptoms during an HAE episode.

Icatibant works by selectively blocking the bradykinin B2 receptor, preventing bradykinin‑mediated vasodilation and increased vascular permeability that lead to the swelling seen in hereditary angioedema.

The dosage and administration schedule are determined by the prescribing healthcare professional based on the patient’s clinical condition and applicable regulatory guidelines. Icatibant is administered as a subcutaneous injection.

Safety data for icatibant in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the prescriber.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping (including cold‑chain if required) and import documentation.

The main alternative is C1‑inhibitor concentrate, a plasma‑derived protein given intravenously. Icatibant is a small‑molecule antagonist administered subcutaneously, allowing self‑administration and targeting the bradykinin receptor directly, whereas C1‑inhibitor replaces the deficient protein.

Icatibant Aguettant should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. If a temperature excursion occurs, follow the manufacturer’s guidance before use.

The medication is supplied as a sterile solution for injection and is administered subcutaneously, usually into the abdomen or thigh, using the provided pre‑filled syringe or vial as directed by a qualified healthcare professional.

Serious adverse reactions include hypersensitivity or anaphylaxis, severe hypotension, and angioedema of the face or throat that could compromise the airway. Immediate medical attention is required if any of these signs develop.

Patients with known hypersensitivity to icatibant or any of its excipients should avoid the product. Additionally, individuals for whom the prescriber determines that the risks outweigh the benefits should not be treated with icatibant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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