Product image of Icatibant Eg (Icatibant) supplied by GNH India

Icatibant Eg

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Eg (Icatibant)

Icatibant, the active ingredient in Icatibant Eg, is a bradykinin B2 receptor antagonist presented as a subcutaneous solution for injection use. It is indicated for the treatment of acute attacks of hereditary angioedema type I and II in patients with confirmed diagnosis.
GNH India supplies Icatibant Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eg S.P.A.

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Indications & Clinical Uses

  • Icatibant acts on the bradykinin pathway to relieve swelling in hereditary angioedema.
  • Acute hereditary angioedema (HAE) type I and II: rapidly reduces edema and associated pain during an attack.

How It Works

  • Icatibant selectively blocks the bradykinin B2 receptor on vascular endothelial cells, preventing bradykinin‑induced vasodilation and increased vascular permeability. By inhibiting this receptor, the drug curtails the cascade that leads to fluid extravasation and swelling characteristic of hereditary angioedema attacks.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or erythema: localized skin reddening.
  • Swelling at injection site: transient increase in tissue volume.
  • Nausea: occasional gastrointestinal upset.
  • Headache: mild to moderate head pain.
  • Fatigue: feeling of tiredness.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Angioedema of the face or throat: potentially life‑threatening swelling.
  • Hypotension: sudden drop in blood pressure.
  • Urticaria: widespread hives.
  • Severe injection‑site necrosis: tissue death at the site.
  • Systemic allergic reaction: rash, fever, or chills.

Precautions & Warnings

  • Before using Icatibant, consider the following safety measures.
  • Allergy assessment: avoid if known hypersensitivity to icatibant or formulation components.
  • Pregnancy and lactation: use only if the potential benefit outweighs risk; data are limited.
  • Renal or hepatic impairment: monitor patients with severe organ dysfunction.
  • Concurrent bradykinin‑modulating therapy: evaluate risk of additive effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant may interact with other agents that influence bradykinin levels or vascular tone.

Major Interactions (Avoid)

  • ACE inhibitors: may increase bradykinin and heighten risk of angioedema.
  • Angiotensin receptor blockers (ARBs): similar potential to raise bradykinin.
  • Estrogen‑containing oral contraceptives: can predispose to angioedema.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may exacerbate swelling or pain.
  • Diuretics: monitor blood pressure changes.
  • Other B2 receptor antagonists: assess cumulative effect on bradykinin blockade.

Frequently Asked Questions

Icatibant Eg is used to treat acute attacks of hereditary angioedema (HAE) types I and II. It works by rapidly reducing swelling and associated pain during an HAE episode.

Icatibant is a selective antagonist of the bradykinin B2 receptor. By blocking this receptor, it prevents bradykinin‑induced vasodilation and vascular permeability, which are key drivers of the swelling seen in HAE.

The dose of Icatibant Eg is determined by the prescribing clinician based on the patient’s condition and regulatory guidelines. Dosage instructions are provided on the prescription label.

Safety data for Icatibant in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Icatibant is a bradykinin B2 receptor antagonist, whereas other HAE therapies such as C1‑esterase inhibitor concentrates replace deficient protein or use monoclonal antibodies targeting kallikrein. Icatibant offers a subcutaneous route and rapid onset, making it suitable for self‑administration during attacks.

Icatibant Eg should be stored at 2‑8 °C (refrigerated). Keep the product in its original container, protect it from light, and do not freeze or shake the vial before use.

Icatibant Eg is given by subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a trained healthcare professional or, after appropriate training, by the patient themselves.

The most serious risks include anaphylaxis, severe angioedema of the face or throat, and hypotension. Patients should be monitored for signs of allergic reaction and instructed to seek immediate medical help if these occur.

Icatibant should not be used by individuals with known hypersensitivity to icatibant or any excipients in the formulation. Caution is also advised for patients with severe renal or hepatic impairment, and those taking ACE inhibitors or estrogen‑containing contraceptives without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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