Product image of Icatibant Glenmark (Icatibant) supplied by GNH India

Icatibant Glenmark

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Glenmark (Icatibant)

Icatibant, the active ingredient in Icatibant Glenmark, is a bradykinin B2 receptor antagonist presented as a subcutaneous formulation for injection use. It is indicated for the treatment of acute attacks of hereditary angioedema type I and II in patients who require rapid symptom control.

GNH India supplies Icatibant Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Pharmaceuticals S.R.O.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Icatibant acts on the bradykinin pathway to relieve swelling in hereditary angioedema.

  • Hereditary angioedema type I: rapid reduction of acute swelling episodes.
  • Hereditary angioedema type II: rapid reduction of acute swelling episodes.
  • Hereditary angioedema (any type): mitigation of attack severity and duration.

How It Works

  • Icatibant selectively blocks the bradykinin B2 receptor, preventing bradykinin‑induced vasodilation and increased vascular permeability. By antagonizing this receptor, the drug curtails the cascade that leads to fluid extravasation and tissue swelling, providing prompt relief of hereditary angioedema attacks.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or erythema: localized skin discoloration.
  • Swelling at injection site: transient increase in tissue volume.
  • Nausea: occasional gastrointestinal upset.
  • Headache: mild to moderate head discomfort.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Hypersensitivity reactions: rash, itching, or hives.
  • Anaphylaxis: severe, potentially life‑threatening allergic response.
  • Severe hypotension: marked drop in blood pressure.
  • Angioedema unrelated to HAE: unexpected swelling.
  • Injection‑site infection: signs of local infection.
  • Thrombosis: rare clot formation at or near injection site.

Precautions & Warnings

Before using Icatibant, consider the following safety measures.

  • Renal impairment: monitor renal function and adjust clinical observation.
  • Hepatic impairment: use with caution and observe liver enzymes.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Concomitant ACE inhibitors: monitor for enhanced bradykinin effects.
  • History of hypersensitivity: avoid if prior allergic reaction to the drug.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant may interact with other medicines; review the following.

Major Interactions (Avoid)

  • ACE inhibitors: additive increase in bradykinin levels may worsen edema.
  • Angiotensin receptor blockers: similar risk of heightened bradykinin activity.
  • Other bradykinin B2 antagonists: potential for overlapping pharmacologic effect.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor blood pressure and electrolyte balance.
  • NSAIDs: observe for increased risk of swelling or renal effects.
  • Corticosteroids: watch for altered immune response at injection site.

Frequently Asked Questions

Icatibant Glenmark is used to treat acute attacks of hereditary angioedema type I and type II. By rapidly blocking the bradykinin B2 receptor, it helps reduce swelling and discomfort during an HAE episode.

Icatibant works as a selective antagonist of the bradykinin B2 receptor. By binding to this receptor, it prevents bradykinin‑mediated vasodilation and increased vascular permeability, which are the primary drivers of swelling in hereditary angioedema.

The dose of icatibant is determined by the prescribing clinician based on the patient’s condition, severity of the attack, and clinical guidelines. The prescriber will specify the exact amount and frequency for each individual case.

Safety data for icatibant in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Icatibant is a bradykinin B2 receptor antagonist, whereas other HAE therapies may target C1‑esterase inhibitor replacement or kallikrein inhibition. Icatibant offers a rapid, subcutaneous option for on‑demand treatment, while alternative agents may be administered intravenously or have different mechanisms of action.

Icatibant Glenmark should be stored at 2‑8 °C (refrigerated). Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial to maintain stability.

Icatibant is given by subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a trained healthcare professional or, in some cases, by the patient after appropriate instruction.

Serious risks include hypersensitivity reactions such as anaphylaxis, severe hypotension, and rare cases of unexpected angioedema unrelated to hereditary angioedema. Patients should be monitored for any signs of allergic reaction or sudden blood pressure changes after administration.

Individuals with a known hypersensitivity to icatibant or any of its excipients should avoid its use. Caution is also advised for patients with severe renal or hepatic impairment, and those taking ACE inhibitors or other drugs that increase bradykinin levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Icatibant

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT