Product image of Icatibant Hikma (Icatibant) supplied by GNH India

Icatibant Hikma

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Hikma (Icatibant)

Icatibant, the active ingredient in Icatibant Hikma, is a bradykinin B2 receptor antagonist presented as an injectable solution for intravenous use. It is used to treat acute attacks of hereditary angioedema in patients who experience sudden swelling.

GNH India supplies Icatibant Hikma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hikma Farmacêutica (Portugal), S.A.

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Indications & Clinical Uses

Icatibant is a targeted therapy for the hereditary angioedema pathway, providing rapid relief of swelling during attacks.

  • Hereditary angioedema type I: reduces swelling and associated pain.
  • Hereditary angioedema type II: alleviates edema and improves airway patency.
  • Hereditary angioedema with normal C1‑INH: controls acute symptom episodes.

How It Works

  • Icatibant acts as a competitive antagonist at the bradykinin B2 receptor, preventing bradykinin from binding and triggering vasodilation and increased vascular permeability. By blocking this receptor, the drug limits the cascade that leads to rapid fluid extravasation and tissue swelling characteristic of hereditary angioedema attacks.

Side Effects

Icatibant may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Injection site pain: discomfort at the site of administration.
  • Redness or swelling at injection site: localized inflammatory response.
  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Flushing: temporary warmth and reddening of skin.

Serious or Rare Side Effects

  • Hypersensitivity reactions: rash, urticaria, or anaphylaxis.
  • Severe hypotension: marked drop in blood pressure.
  • Thrombocytopenia: low platelet count.
  • Acute respiratory distress: difficulty breathing unrelated to swelling.
  • Cardiac arrhythmias: irregular heart rhythm.

Precautions & Warnings

When using Icatibant, clinicians should consider several safety measures.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown excretion; weigh potential benefits against infant exposure.
  • Renal impairment: monitor patients with severe kidney dysfunction.
  • Concomitant ACE inhibitors: observe for additive bradykinin effects.
  • History of hypersensitivity: avoid if prior severe allergic reaction to the drug.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant can interact with other agents that influence bradykinin pathways or cardiovascular function.

Major Interactions (Avoid)

  • ACE inhibitors: may increase bradykinin levels, heightening risk of angioedema.
  • Angiotensin receptor blockers (ARBs): similar risk of enhanced bradykinin activity.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor blood pressure for additive hypotensive effect.
  • Antihistamines: may mask early signs of hypersensitivity.
  • Other B2 receptor antagonists: avoid concurrent use due to overlapping mechanisms.

Frequently Asked Questions

Icatibant Hikma is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in patients who experience sudden, potentially life‑threatening swelling of the skin, gastrointestinal tract, or airway.

Icatibant blocks the bradykinin B2 receptor, preventing bradykinin from causing vasodilation and increased vascular permeability. This inhibition stops the rapid fluid leakage that leads to swelling during an HAE attack.

The dose and administration schedule are determined by the prescribing clinician based on the patient’s condition, severity of the attack, and clinical guidelines. No fixed regimen is provided here.

Safety data for Icatibant in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Icatibant is a selective bradykinin B2 receptor antagonist, whereas other options such as C1‑esterase inhibitor concentrates replace a deficient protein. Icatibant provides rapid symptom relief via a different mechanism and is administered subcutaneously, offering an alternative for patients who prefer a non‑protein therapy.

Icatibant should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. If temporary storage at room temperature is unavoidable, limit exposure to less than 30 °C for no more than 24 hours.

The medication is supplied as an injectable solution for intravenous use. It is administered by a qualified healthcare professional, typically as a single dose during an acute HAE attack, with additional doses given if the response is insufficient.

Serious risks include hypersensitivity reactions such as anaphylaxis, severe hypotension, thrombocytopenia, and rare cardiac arrhythmias. Patients should be monitored closely after administration, and any signs of severe reaction require immediate medical attention.

Patients with a known hypersensitivity to Icatibant or any of its excipients should avoid the drug. Caution is also advised for individuals with severe renal impairment, uncontrolled hypertension, or those taking ACE inhibitors or ARBs without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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