Product image of Icatibant Newbury (Icatibant) supplied by GNH India

Icatibant Newbury

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Newbury (Icatibant)

Icatibant, the active ingredient in Icatibant Newbury, is a Bradykinin B2 receptor antagonist presented as a subcutaneous formulation for subcutaneous use. It is indicated for the treatment of hereditary angioedema attacks in patients with C1‑inhibitor deficiency.

GNH India supplies Icatibant Newbury as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance and reliable logistics for global healthcare providers. The company adheres to stringent manufacturing standards and provides comprehensive support for product handling and distribution.

Manufacturer / TM Owner

Newbury Pharmaceuticals Ab

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Indications & Clinical Uses

Icatibant acts on the bradykinin pathway to relieve swelling in hereditary angioedema.

  • Hereditary angioedema (C1‑inhibitor deficiency): provides rapid relief of acute swelling episodes.
  • Hereditary angioedema type I: reduces the severity and duration of attacks.
  • Hereditary angioedema type II: alleviates symptoms during acute episodes.

How It Works

  • Icatibant selectively blocks the bradykinin B2 receptor on vascular endothelial cells, preventing bradykinin‑mediated vasodilation and increased vascular permeability. By inhibiting this receptor, the drug stops the cascade that leads to fluid extravasation and tissue swelling, thereby controlling acute hereditary angioedema attacks.

Side Effects

Icatibant may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Injection site pain: discomfort at the site of subcutaneous administration.
  • Redness or erythema: localized skin irritation.
  • Swelling at injection site: transient edema.
  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: temporary light‑headedness.

Serious or Rare Side Effects

  • Hypersensitivity reactions: rash, itching, or hives.
  • Anaphylaxis: severe, potentially life‑threatening allergic response.
  • Severe hypotension: marked drop in blood pressure.
  • Airway angioedema: swelling that may compromise breathing.
  • Thrombocytopenia: low platelet count observed in rare cases.

Precautions & Warnings

Before using Icatibant, consider the following safety measures.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: caution advised; limited information on excretion in milk.
  • Renal impairment: monitor patients; no specific dosage adjustment is established.
  • Concomitant ACE inhibitors or ARBs: increased risk of angioedema; use with caution.
  • Known hypersensitivity: avoid in patients with documented allergy to icatibant or its excipients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant can interact with other medicines that affect the bradykinin system or vascular tone.

Major Interactions (Avoid)

  • ACE inhibitors: may increase the risk of angioedema.
  • Angiotensin receptor blockers (ARBs): potential additive effect on bradykinin‑mediated swelling.

Moderate Interactions (Monitor Closely)

  • Estrogen‑containing contraceptives: may exacerbate hereditary angioedema.
  • Diuretics: can influence fluid balance and blood pressure.
  • Other bradykinin pathway modulators: may alter therapeutic response.

Frequently Asked Questions

Icatibant Newbury is used to treat acute attacks of hereditary angioedema in patients with C1‑inhibitor deficiency. By blocking the bradykinin B2 receptor, it rapidly reduces swelling and associated symptoms during an episode.

Icatibant works by selectively antagonizing the bradykinin B2 receptor on blood vessels. This blocks bradykinin‑induced vasodilation and increased vascular permeability, which are the primary drivers of swelling in hereditary angioedema.

The dose of icatibant is determined by the prescribing healthcare professional based on the patient’s condition and clinical guidelines. Only a qualified prescriber can set the appropriate dosing regimen.

Safety data for icatibant in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Icatibant is a bradykinin B2 receptor antagonist, whereas other options such as C1‑inhibitor concentrates replace the deficient protein. Icatibant provides a rapid, targeted approach for acute attacks, while C1‑inhibitor products can be used for both acute treatment and prophylaxis.

Icatibant should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until ready for use to maintain stability.

Icatibant is administered by subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a trained healthcare professional or, in some cases, by the patient after appropriate instruction.

Serious risks include hypersensitivity reactions such as anaphylaxis, severe hypotension, and airway angioedema that can compromise breathing. Patients should be monitored closely for any signs of these reactions after administration.

Icatibant should not be used by individuals with known hypersensitivity to the drug or any of its excipients. Caution is also advised for patients taking ACE inhibitors, ARBs, or those with uncontrolled cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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