Product image of Icatibant Piramal (Icatibant) supplied by GNH India

Icatibant Piramal

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Piramal (Icatibant)

Icatibant, the active ingredient in Icatibant Piramal, is a Bradykinin B2 receptor antagonist presented as a solution for injection for subcutaneous use. It treats hereditary angioedema attacks in patients with a confirmed diagnosis.

GNH India supplies Icatibant Piramal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Piramal Critical Care B.V.

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Indications & Clinical Uses

Icatibant is a selective bradykinin B2 receptor antagonist used in the management of hereditary angioedema.

  • Hereditary angioedema type I: provides rapid reduction of swelling during acute attacks.
  • Hereditary angioedema type II: alleviates edema by blocking bradykinin effects.
  • Acute HAE attacks in adults: delivers prompt symptom control to improve patient comfort.

How It Works

  • Icatibant binds selectively to the bradykinin B2 receptor, preventing bradykinin from activating the receptor. This inhibition blocks the downstream signaling that leads to vasodilation and increased vascular permeability, thereby reducing the swelling characteristic of hereditary angioedema attacks.

Side Effects

Icatibant may cause a range of adverse reactions following subcutaneous administration.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Erythema: localized redness around the injection area.
  • Nausea: occasional feeling of queasiness after dosing.
  • Headache: transient head pain reported by some patients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Hypotension: sudden drop in blood pressure that may cause dizziness.
  • Angioedema at injection site: swelling that can extend beyond the local area.
  • Urticaria: hives or widespread skin rash.

Precautions & Warnings

Before using Icatibant, consider the following safety measures.

  • Pregnancy: safety not established; use only if benefits outweigh potential risks.
  • Breastfeeding: unknown effects; evaluate risk versus benefit.
  • Renal impairment: administer with caution and monitor renal function.
  • Concomitant ACE inhibitors: may increase risk of angioedema; monitor closely.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant can interact with other medicines that affect bradykinin pathways.

Major Interactions (Avoid)

  • ACE inhibitors: may potentiate bradykinin effects, raising angioedema risk.
  • Neprilysin inhibitors (e.g., sacubitril): increase bradykinin levels, potentially worsening swelling.

Moderate Interactions (Monitor Closely)

  • Estrogen‑containing oral contraceptives: may exacerbate hereditary angioedema.
  • Angiotensin receptor blockers: possible additive effect on bradykinin activity.
  • Diuretics: monitor fluid balance and blood pressure during therapy.

Frequently Asked Questions

Icatibant Piramal is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in patients with a confirmed diagnosis, helping to rapidly reduce swelling and improve comfort during an episode.

Icatibant selectively blocks the bradykinin B2 receptor, preventing bradykinin‑mediated vasodilation and increased vascular permeability that cause the swelling characteristic of hereditary angioedema.

The prescribed dose is determined by the treating clinician based on the patient’s condition, regulatory guidance, and individual response; specific dosing regimens are not provided in this summary.

Safety data for icatibant during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping (including cold‑chain if required) and import documentation.

Icatibant is a small‑molecule B2‑receptor antagonist administered subcutaneously, whereas alternatives such as C1‑esterase inhibitor concentrates are protein‑based and given intravenously. Choice depends on factors like route preference, speed of onset, and individual safety profile.

The solution for injection should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until ready for use.

Icatibant is delivered by subcutaneous injection, usually into the abdomen or thigh, using a pre‑filled syringe. Administration can be performed by a healthcare professional or a trained patient following aseptic technique.

Serious adverse events include hypersensitivity reactions such as anaphylaxis, severe hypotension, and rare cases of angioedema at the injection site. Patients should be observed for these signs after each dose.

Icatibant is contraindicated in individuals with known hypersensitivity to icatibant or any of its excipients. Caution is advised for patients with severe cardiovascular disease or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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