Product image of Icatibant Teva (Icatibant Acetate) supplied by GNH India

Icatibant Teva

Active Ingredient:
Icatibant Acetate
Origin:
EU

Icatibant Teva (Icatibant Acetate)

Icatibant acetate, the active ingredient in Icatibant Teva, is a bradykinin B2 receptor antagonist presented as a subcutaneous injection solution for subcutaneous use. It treats acute attacks of hereditary angioedema in patients with a confirmed diagnosis, providing rapid reduction of swelling and pain.

GNH India supplies Icatibant Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is manufactured to EU standards and distributed under strict quality controls to ensure consistency across global markets.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

  • Icatibant Teva is a bradykinin B2 receptor antagonist that acts on the kallikrein‑kinin system to treat hereditary angioedema.
  • Acute hereditary angioedema attacks (type I and II): rapid reduction of subcutaneous and submucosal swelling, alleviating pain and preventing airway obstruction.

How It Works

  • Icatibant acetate binds competitively to the bradykinin B2 receptor on vascular endothelial cells, blocking bradykinin from activating the receptor. This inhibition prevents bradykinin‑mediated vasodilation and increased vascular permeability, thereby reducing the edema and pain associated with hereditary angioedema attacks.

Side Effects

Icatibant Teva may cause a range of adverse reactions following subcutaneous administration.

Common Side Effects

  • Injection site pain: discomfort at the injection site.
  • Erythema: redness around the injection area.
  • Local swelling: mild edema at the site.
  • Pruritus: itching at or near the injection site.
  • Nausea: occasional upset stomach.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe hypersensitivity: rash, bronchospasm, or angioedema unrelated to HAE.
  • Hypotension: sudden drop in blood pressure, potentially causing dizziness or fainting.

Precautions & Warnings

  • Before using Icatibant Teva, consider the following safety measures.
  • Assess hypersensitivity: verify no known allergy to icatibant or formulation components.
  • Monitor cardiovascular status: observe for hypotension or tachycardia after injection.
  • Use caution in renal or hepatic impairment: adjust monitoring as needed.
  • Avoid concomitant ACE inhibitors: increased risk of angioedema.
  • Educate patients on self‑administration: ensure proper injection technique and site rotation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant Teva has limited drug‑drug interactions, but certain combinations require attention.

Major Interactions (Avoid)

  • ACE inhibitors: may increase bradykinin levels and heighten angioedema risk.
  • Other bradykinin B2 antagonists: concurrent use can reduce therapeutic effectiveness.

Moderate Interactions (Monitor Closely)

  • Estrogen‑containing contraceptives: may influence hereditary angioedema severity.
  • C1‑esterase inhibitor concentrates: may alter the clinical response when used together.
  • Antihistamines: monitor for additive effects on blood pressure.

Frequently Asked Questions

Icatibant Teva is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in patients with confirmed type I or type II disease. It provides rapid relief of swelling and pain associated with HAE episodes.

Icatibant acetate acts as a competitive antagonist at the bradykinin B2 receptor. By blocking this receptor, it prevents bradykinin‑induced vasodilation and increased vascular permeability, which are the primary drivers of swelling in hereditary angioedema.

The dosing regimen for Icatibant Teva is determined by the prescribing healthcare professional based on the patient’s clinical condition, severity of the HAE attack, and individual response. Patients should follow the prescriber’s instructions precisely.

Safety data for icatibant acetate in pregnancy and lactation are limited, and the product’s pregnancy category is unknown. Use only if the potential benefit justifies the potential risk, and discuss with a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and import documentation.

Icatibant Teva is a bradykinin B2 receptor antagonist, whereas other approved options include C1‑esterase inhibitor concentrates and plasma‑derived products. Icatibant offers a subcutaneous route and rapid onset, making it suitable for self‑administration during acute attacks.

The product should be stored at 2‑8 °C (refrigerated), protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

Icatibant Teva is supplied as a sterile solution for subcutaneous injection. The patient or caregiver injects the prescribed dose into the subcutaneous tissue, typically in the abdomen or thigh, following aseptic technique and the prescriber’s instructions.

The most serious risks include severe hypersensitivity reactions such as anaphylaxis and paradoxical angioedema unrelated to HAE. Immediate medical attention is required if signs of a severe allergic reaction occur.

Patients with known hypersensitivity to icatibant acetate or any component of the formulation should avoid use. Additionally, individuals taking ACE inhibitors who have a history of angioedema should be evaluated carefully before treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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