Product image of Icatibant Viatris (Icatibant) supplied by GNH India

Icatibant Viatris

Active Ingredient:
Icatibant
Origin:
EU

Icatibant Viatris (Icatibant)

Icatibant, the active ingredient in Icatibant Viatris, is a Bradykinin B2 receptor antagonist presented as an injection solution for subcutaneous use. It treats acute attacks of hereditary angioedema in patients who experience sudden, potentially life‑threatening swelling.
GNH India supplies Icatibant Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Icatibant is used to manage bradykinin‑mediated angioedema conditions, providing rapid symptom relief.

  • Hereditary angioedema (type I/II): reduces swelling during acute attacks.
  • Hereditary angioedema (type III/normal C1‑INH): controls symptoms of sudden edema.
  • Acute bradykinin‑mediated angioedema: alleviates swelling when conventional therapy is insufficient.

How It Works

  • Icatibant acts as a competitive antagonist at the bradykinin B2 receptor, blocking the binding of endogenous bradykinin. By preventing receptor activation, it inhibits bradykinin‑induced vasodilation and increased vascular permeability, thereby reducing the formation of edema associated with hereditary angioedema attacks.

Side Effects

Icatibant may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Injection site pain: mild discomfort at the injection site.
  • Redness or swelling at injection site: localized erythema.
  • Nausea: occasional feeling of queasiness.
  • Headache: transient mild headache.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypotension: sudden drop in blood pressure.
  • Laryngeal edema: swelling of the throat that may impair breathing.

Precautions & Warnings

When using Icatibant, consider the following safety measures.

  • Hypersensitivity monitoring: watch for signs of allergic reaction.
  • Cardiovascular caution: use carefully in patients with known heart disease.
  • Renal/hepatic assessment: evaluate function before initiating therapy.
  • Contraindication: avoid in individuals with known hypersensitivity to icatibant.
  • Pregnancy and lactation: safety not established; weigh risks and benefits.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • ACE inhibitors: may increase bradykinin levels, heightening risk of angioedema.
  • Angiotensin receptor blockers: similar potential to augment bradykinin effects.
  • Other bradykinin B2 antagonists: additive pharmacologic activity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may mask early signs of an allergic reaction.
  • Estrogen‑containing contraceptives: can influence frequency of HAE attacks.
  • Concurrent biologics: monitor for overlapping immunologic effects.

Frequently Asked Questions

Icatibant Viatris is indicated for the treatment of acute attacks of hereditary angioedema. It works by rapidly reducing swelling caused by excess bradykinin, providing relief during sudden episodes of facial, peripheral, or airway edema.

Icatibant blocks the bradykinin B2 receptor, preventing bradykinin from binding and triggering vasodilation and increased vascular permeability. This inhibition stops the cascade that leads to the swelling characteristic of hereditary angioedema attacks.

The prescribed dose of Icatibant Viatris is determined by the treating physician based on the patient’s clinical condition and regulatory guidelines. Dosing instructions are individualized and should be followed exactly as written on the prescription.

Safety data for Icatibant Viatris in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks before prescribing it to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Icatibant is a selective bradykinin B2 receptor antagonist, whereas other options such as C1‑esterase inhibitor concentrates replace the deficient protein. Icatibant offers a subcutaneous route and rapid onset, making it useful for patients who prefer self‑administration and need quick symptom control.

Icatibant Viatris should be stored at 2‑8 °C in a refrigerator. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial to maintain stability.

The medication is supplied as a sterile injection solution for subcutaneous injection. A healthcare professional or the patient (after proper training) injects the dose into the subcutaneous tissue, typically in the abdomen or thigh, following aseptic technique.

Serious risks include anaphylactic reactions, severe hypotension, and laryngeal edema that can compromise breathing. Patients should be monitored after injection, and any signs of severe allergic response or airway obstruction require immediate medical attention.

Icatibant Viatris is contraindicated in individuals with known hypersensitivity to icatibant or any of its excipients. Patients with a history of severe allergic reactions to bradykinin B2 antagonists should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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