Product image of Icatibanto Gp-Pharm (Icatibant) supplied by GNH India

Icatibanto Gp-Pharm

Active Ingredient:
Icatibant
Origin:
EU

Icatibanto Gp-Pharm (Icatibant)

Icatibant, the active ingredient in Icatibanto Gp-Pharm, is a Bradykinin B2 receptor antagonist presented as a solution for injection for subcutaneous use. It treats hereditary angioedema attacks in patients with hereditary angioedema.

GNH India supplies Icatibanto Gp-Pharm as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gp-Pharm S.A.

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Indications & Clinical Uses

Icatibant is a targeted therapy for hereditary angioedema, acting on the bradykinin pathway to relieve acute swelling.

  • Hereditary angioedema type I: rapid relief of swelling during acute attacks.
  • Hereditary angioedema type II: reduces attack severity and duration.
  • Hereditary angioedema with normal C1-INH (HAE‑nC1‑INH): provides symptom control during attacks.

How It Works

  • Icatibant selectively blocks the bradykinin B2 receptor, preventing bradykinin from binding and triggering vasodilation and increased vascular permeability. By inhibiting this receptor, the drug reduces the fluid leakage and swelling that characterize hereditary angioedema attacks, offering rapid symptom relief.

Side Effects

Icatibant may cause a range of adverse reactions, from mild injection‑site discomfort to rare but serious hypersensitivity events.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or erythema: localized skin reddening.
  • Swelling at injection site: transient edema.
  • Nausea: occasional gastrointestinal upset.
  • Headache: mild to moderate intensity.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Angioedema: unexpected swelling of face, lips, or throat.
  • Hypotension: sudden drop in blood pressure.
  • Thrombocytopenia: low platelet count.
  • Severe hypersensitivity: rash, fever, or organ involvement.
  • Injection‑site necrosis: rare tissue damage.

Precautions & Warnings

Before using Icatibant, consider the following safety measures.

  • Pregnancy: safety unknown; avoid unless benefit outweighs risk.
  • Breastfeeding: unknown safety; assess potential infant exposure.
  • Renal impairment: use with caution; monitor renal function.
  • Concomitant ACE inhibitors: monitor for increased bradykinin‑related effects.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant can interact with other agents that affect bradykinin or vascular tone.

Major Interactions (Avoid)

  • ACE inhibitors: may increase risk of angioedema.
  • Renin‑angiotensin system blockers: additive bradykinin effects.

Moderate Interactions (Monitor Closely)

  • Estrogen‑containing contraceptives: may exacerbate hereditary angioedema.
  • NSAIDs: potential to increase swelling risk.
  • Other bradykinin‑modulating agents: monitor for additive pharmacodynamic effects.

Frequently Asked Questions

Icatibanto Gp-Pharm contains icatibant, a Bradykinin B2 receptor antagonist indicated for the treatment of acute hereditary angioedema attacks in patients with hereditary angioedema. It helps to quickly reduce swelling and improve airway patency during an attack.

Icatibant works by selectively blocking the bradykinin B2 receptor, which prevents bradykinin‑induced vasodilation and increased vascular permeability. This inhibition stops the fluid leakage that causes the swelling characteristic of hereditary angioedema.

The dose of Icatibanto Gp-Pharm is determined by the prescribing healthcare professional based on the patient’s condition, weight, and clinical response. The prescriber will specify the exact amount and frequency for each individual.

Safety data for icatibant in pregnancy and lactation are limited. It is classified as pregnancy category unknown, and use is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Icatibant is a selective bradykinin B2 receptor antagonist, whereas other options such as C1‑esterase inhibitor concentrates replace a deficient protein. Icatibant provides rapid symptom relief via subcutaneous injection, while C1‑INH products are administered intravenously and act by restoring the missing inhibitor.

Icatibanto Gp-Pharm should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep it in the original packaging until use to maintain stability.

The medication is supplied as a solution for injection and is given subcutaneously. A healthcare professional or trained individual injects the prescribed dose into the subcutaneous tissue, typically in the abdomen or thigh, following aseptic technique.

Serious risks include anaphylaxis, severe hypersensitivity reactions, unexpected angioedema, and hypotension. Patients should be monitored after injection, and any signs of severe allergic reaction or rapid blood pressure drop require immediate medical attention.

Icatibanto Gp-Pharm is contraindicated in individuals with known hypersensitivity to icatibant or any of the formulation components. Patients with a history of severe allergic reactions to bradykinin antagonists should avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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