Product image of Iccofen (Diclofenac Diethylamine) supplied by GNH India

Iccofen

Active Ingredient:
Diclofenac Diethylamine
Origin:
EU

Iccofen (Diclofenac Diethylamine)

Diclofenac diethylamine, the active ingredient in Iccofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for local use. It relieves pain and inflammation associated with musculoskeletal conditions such as sprains, strains, and osteoarthritis.

GNH India supplies Iccofen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Hungária Kft

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Indications & Clinical Uses

Diclofenac diethylamine is applied topically to address inflammatory and painful conditions of the musculoskeletal system.

  • Musculoskeletal pain: reduces pain and inflammation in muscles and joints.
  • Sprains and strains: alleviates swelling and discomfort after soft‑tissue injury.
  • Osteoarthritis: improves joint mobility and lessens chronic joint pain.
  • Tendinitis: diminishes localized inflammation and facilitates functional recovery.

How It Works

  • Diclofenac diethylamine penetrates the skin and reversibly inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of application, it provides localized anti‑inflammatory and analgesic effects without significant systemic exposure.

Side Effects

Topical diclofenac may cause skin‑related reactions and, rarely, systemic adverse events.

Common Side Effects

  • Skin irritation: redness, itching, or burning at the application site.
  • Dryness or peeling of the skin.
  • Localized rash or contact dermatitis.

Serious or Rare Side Effects

  • Allergic reactions: swelling, hives, or anaphylaxis.
  • Severe skin disorders: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic toxicity: gastrointestinal ulceration, renal impairment, or hepatic dysfunction, especially with extensive use.

Precautions & Warnings

Before using Iccofen, consider the following safety measures.

  • Skin integrity: avoid applying to broken, infected, or irritated skin.
  • Allergy history: do not use if you have known hypersensitivity to diclofenac, other NSAIDs, or excipients.
  • Pregnancy: avoid use during the third trimester due to potential fetal risk.
  • Concomitant NSAIDs: limit simultaneous use of other NSAIDs to reduce systemic exposure.
  • Underlying disease: use with caution in patients with renal, hepatic, or cardiovascular disorders.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac diethylamine can interact with several systemic medications.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal and renal toxicity.
  • Lithium: elevated lithium serum levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: additive risk of ulceration.
  • Antihypertensives (e.g., ACE inhibitors, diuretics): possible reduction in antihypertensive effect.
  • Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding tendency.

Frequently Asked Questions

Iccofen is a topical formulation of diclofenac diethylamine indicated for the relief of pain and inflammation associated with musculoskeletal conditions such as sprains, strains, osteoarthritis, and other localized joint or soft‑tissue injuries.

Diclofenac diethylamine penetrates the skin and blocks the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the production of prostaglandins. Lower prostaglandin levels diminish inflammation and pain at the site where the product is applied.

The appropriate amount and frequency of Iccofen are determined by the prescribing healthcare professional based on the severity of the condition, the area of application, and individual patient factors. Patients should follow the prescriber’s instructions and the product label.

Diclofenac-containing topical products are generally avoided in the third trimester of pregnancy because of potential fetal risks. Safety during early pregnancy and lactation has not been fully established, so a healthcare provider should be consulted before use.

To request Iccofen, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Iccofen contains diclofenac diethylamine, a potent NSAID that offers strong local anti‑inflammatory activity. Compared with other topical NSAIDs such as ibuprofen or ketoprofen gels, diclofenac often provides faster pain relief and is widely studied for musculoskeletal conditions, though individual response may vary.

Store Iccofen at room temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, excessive heat, and direct sunlight to maintain stability and efficacy.

Iccofen is applied topically to clean, dry skin over the affected area. A thin layer is spread gently and rubbed in until absorbed, usually 2‑4 times daily, or as directed by the prescriber. Hands should be washed after application unless they are the treatment site.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and systemic effects like gastrointestinal ulceration, renal impairment, or hepatic dysfunction, especially with extensive or prolonged use.

Individuals with a known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation should avoid Iccofen. It is also contraindicated on broken or infected skin, in the third trimester of pregnancy, and in patients with severe renal, hepatic, or cardiovascular disease without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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