Product image of Icomb 10 Mg/10 Mg Capsule Rigide (Ramipril, Amlodipine Besilate) supplied by GNH India

Icomb 10 Mg/10 Mg Capsule Rigide

Active Ingredient:
Ramipril, Amlodipine Besilate
Origin:
EU

Icomb 10 Mg/10 Mg Capsule Rigide (Ramipril, Amlodipine Besilate)

Ramipril and amlodipine besilate, the active ingredients in Icomb 10 Mg/10 Mg Capsule Rigide, are an ACE inhibitor and a calcium‑channel blocker presented as a 10 mg/10 mg hard capsule for oral use. They treat hypertension in adult patients.
GNH India supplies Icomb 10 Mg/10 Mg Capsule Rigide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Icomb combines ramipril and amlodipine besilate, an ACE‑inhibitor and calcium‑channel blocker, to manage high blood pressure.

  • Hypertension: lowers systolic and diastolic blood pressure in adults.
  • Essential hypertension: provides sustained blood‑pressure control when monotherapy is insufficient.
  • Isolated systolic hypertension: reduces elevated systolic pressure in elderly patients.

How It Works

  • Ramipril inhibits angiotensin‑converting enzyme, decreasing formation of angiotensin II and reducing vasoconstriction and aldosterone release. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing arterial vasodilation. The combined actions produce additive reduction of systemic vascular resistance and blood pressure.

Side Effects

Icomb may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Cough: persistent dry cough.
  • Dizziness: especially upon standing.
  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: transient warmth and redness.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat.
  • Severe hypotension: marked drop in blood pressure after first dose.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Neutropenia: low white‑blood‑cell count.
  • Anaphylactic reaction: severe allergic response requiring emergency care.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Monitor blood pressure: ensure target levels are achieved without excessive drop.
  • Assess renal function: check creatinine and eGFR periodically.
  • Check electrolytes: especially potassium when combined with diuretics.
  • Avoid in pregnancy: category D, discontinue if pregnancy occurs.
  • Use cautiously in elderly: start at lower dose and monitor for orthostatic hypotension.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Icomb can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: risk of renal impairment and hyperkalemia.
  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., itraconazole): increase amlodipine plasma levels.
  • NSAIDs combined with ACE inhibitor: heightened risk of renal dysfunction.
  • Other antihypertensives: may lead to excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: additive blood‑pressure lowering effect.
  • Lithium: possible increase in lithium concentrations.
  • CYP3A4 inducers (e.g., rifampicin): may reduce amlodipine efficacy.
  • Antidiabetic agents: blood‑glucose control may improve, requiring dose adjustment.
  • NSAIDs alone: may blunt antihypertensive response.

Frequently Asked Questions

Icomb 10 mg/10 mg Capsule Rigide is a fixed‑dose combination of ramipril and amlodipine besilate indicated for the treatment of hypertension in adult patients, helping to lower elevated systolic and diastolic blood pressure when monotherapy does not achieve target control.

Ramipril is an angiotensin‑converting enzyme (ACE) inhibitor; it blocks the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, resulting in reduced vasoconstriction, decreased aldosterone secretion, and ultimately lower blood pressure.

The prescribed dose of Icomb 10 mg/10 mg capsule is determined by the treating physician based on the patient’s blood‑pressure response, renal function, and any concomitant therapies. Dosage adjustments are individualized, and patients should follow the prescriber’s specific instructions.

The combination is classified as pregnancy category D, indicating evidence of risk to the fetus; it should be avoided during pregnancy. Use while breastfeeding is not recommended unless the benefit outweighs potential risk, and a healthcare professional should be consulted.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Adding amlodipine to ramipril provides complementary blood‑pressure reduction; amlodipine’s calcium‑channel blockade causes vasodilation, which can offset the cough associated with ACE inhibitors and improve control in patients not reaching target pressure with ramipril alone. The fixed‑dose simplifies therapy but may increase the risk of peripheral edema.

Store the capsules at ambient temperature below 25 °C, in the original blister pack or container, protected from moisture and direct sunlight. Do not refrigerate or freeze. Keep out of reach of children and ensure the packaging remains intact until use.

Icomb 10 mg/10 mg capsules are taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the capsule whole; do not crush or chew, to maintain the intended release profile.

Patients should be alert for signs of angioedema such as swelling of the face, lips, tongue or throat, which requires immediate medical attention. Severe hypotension, especially after the first dose, and hepatic dysfunction or unexplained jaundice are also serious concerns that warrant prompt evaluation.

The combination should be avoided in patients with known hypersensitivity to ramipril, amlodipine or any excipients, in those with a history of angioedema related to ACE inhibitors, in pregnant women, and in individuals with severe hepatic impairment. Caution is advised in elderly patients and those with renal dysfunction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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