Product image of Icomb 10 Mg/5 Mg Capsule Rigide (Ramipril, Amlodipine Besilate) supplied by GNH India

Icomb 10 Mg/5 Mg Capsule Rigide

Active Ingredient:
Ramipril, Amlodipine Besilate
Origin:
EU

Icomb 10 Mg/5 Mg Capsule Rigide (Ramipril, Amlodipine Besilate)

Ramipril, the active ingredient in Icomb 10 Mg/5 Mg Capsule Rigide, is an ACE inhibitor presented as a 10 mg/5 mg rigid capsule for oral use. Together with amlodipine besilate, it provides antihypertensive therapy for adults with essential hypertension, helping to lower systolic and diastolic blood pressure.

GNH India supplies Icomb 10 Mg/5 Mg Capsule Rigide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide, ensuring consistent quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Icomb 10 Mg/5 Mg Capsule Rigide is indicated for conditions within the hypertension disease family, where it helps control elevated blood pressure.

  • Essential hypertension: reduces systolic and diastolic pressure to target levels.
  • Primary hypertension: provides combined ACE inhibition and calcium‑channel blockade for better blood pressure control.
  • Hypertension in patients requiring dual therapy: offers convenient single‑pill regimen to improve adherence.

How It Works

  • The combination works by two complementary mechanisms. Ramipril inhibits angiotensin‑converting enzyme, decreasing formation of angiotensin II and thereby reducing vasoconstriction and aldosterone‑mediated sodium retention. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, preventing calcium influx and causing arterial vasodilation. Together they produce additive blood‑pressure‑lowering effects with a single oral dose.

Side Effects

Like all antihypertensive agents, Icomb 10 Mg/5 Mg Capsule Rigide may cause adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness or light‑headedness: especially after standing.
  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: sensation of warmth, often on the face.

Serious or Rare Side Effects

  • Angioedema: rapid swelling of lips, tongue or airway, requiring emergency care.
  • Severe hypotension: marked drop in blood pressure leading to fainting.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Icomb 10 Mg/5 Mg Capsule Rigide, clinicians should consider the following precautions.

  • Renal impairment: monitor kidney function and adjust dose if necessary.
  • Hyperkalemia risk: avoid concomitant potassium‑sparing diuretics or supplements.
  • Pregnancy: avoid use because safety in pregnancy is not established.
  • Elderly patients: start at lower dose and monitor for orthostatic hypotension.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Icomb 10 Mg/5 Mg Capsule Rigide can interact with several medicines; awareness of major and moderate interactions helps prevent therapeutic failure or toxicity.

Major Interactions (Avoid)

  • Aliskiren in patients with diabetes: combined renin‑angiotensin blockade may cause renal impairment.
  • Potassium supplements or potassium‑sparing diuretics: increase risk of hyperkalemia.
  • NSAIDs (e.g., ibuprofen, naproxen): may blunt antihypertensive effect and affect kidney function.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): raise amlodipine levels, may cause edema or hypotension.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): lower amlodipine concentrations, reducing efficacy.
  • Loop or thiazide diuretics: additive blood‑pressure lowering, monitor for excessive hypotension.

Frequently Asked Questions

Icomb 10 Mg/5 Mg Capsule Rigide is a prescription medication that combines ramipril and amlodipine besilate to treat hypertension, including essential hypertension, by lowering elevated systolic and diastolic blood pressure in adult patients.

Ramipril blocks the angiotensin‑converting enzyme, reducing angiotensin II production and decreasing vasoconstriction. Amlodipine blocks L‑type calcium channels in vascular smooth muscle, causing arterial dilation. The dual action provides additive blood‑pressure reduction with a single oral dose.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any concomitant medications. The prescriber will select the starting dose and any subsequent adjustments.

Safety in pregnancy has not been established, and the product is generally avoided in pregnant women because of potential fetal risk. Limited data are available for breastfeeding; clinicians usually weigh the benefits against possible risks before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Icomb combines two antihypertensive mechanisms in one pill, offering better blood‑pressure control for patients who need dual therapy while simplifying the regimen. Monotherapy with either ramipril or amlodipine may be less effective in patients requiring both ACE inhibition and calcium‑channel blockade.

Store the capsules at temperatures below 25 °C in their original packaging, protecting them from moisture and direct light. Keep the container tightly closed and out of reach of children.

The medication is taken orally, usually once daily, with or without food. Swallow the rigid capsule whole; do not crush, chew, or split it.

Serious adverse reactions include angioedema (rapid swelling of the face, lips, tongue or airway), severe hypotension that can cause fainting, and hepatic dysfunction indicated by elevated liver enzymes or jaundice. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to ramipril, amlodipine, or any component of the formulation should avoid the product. It is also contraindicated in individuals with a history of angioedema related to ACE inhibitors, severe renal impairment, or those who are pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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