Product image of Icomb 2,5 Mg/2,5 Mg (Ramipril, Amlodipine Besilate) supplied by GNH India

Icomb 2,5 Mg/2,5 Mg

Active Ingredient:
Ramipril, Amlodipine Besilate
Origin:
EU

Icomb 2,5 Mg/2,5 Mg (Ramipril, Amlodipine Besilate)

Ramipril and Amlodipine besilate, the active ingredients in Icomb 2,5 Mg/2,5 Mg, are an ACE inhibitor and a calcium channel blocker presented as a 2.5 mg/2.5 mg oral tablet for oral use. They treat hypertension in adult patients.

GNH India supplies Icomb 2,5 Mg/2,5 Mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Icomb 2,5 Mg/2,5 Mg combines ramipril and amlodipine to manage hypertension, a condition of elevated arterial pressure.

  • Essential hypertension: reduces systolic and diastolic blood pressure, decreasing cardiovascular risk.
  • Secondary hypertension: assists in blood pressure control when underlying causes are present.
  • High blood pressure: provides sustained antihypertensive effect for long‑term management.

How It Works

  • Ramipril inhibits the angiotensin‑converting enzyme, lowering angiotensin II production and reducing vasoconstriction and aldosterone‑mediated sodium retention. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing arterial dilation. Together they lower peripheral resistance and cardiac afterload, producing a synergistic reduction in blood pressure.

Side Effects

Icomb 2,5 Mg/2,5 Mg may be associated with several adverse reactions, which are categorized by frequency.

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness or light‑headedness: especially after first doses.
  • Peripheral edema: swelling of ankles or feet.
  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or airway.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Myocardial infarction: rare but reported cardiac events.

Precautions & Warnings

Before prescribing Icomb 2,5 Mg/2,5 Mg, clinicians should consider several precautionary measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Renal function: assess creatinine clearance in patients with renal impairment.
  • Hepatic disease: use cautiously in moderate to severe liver dysfunction.
  • Pregnancy: avoid use during pregnancy due to fetal risk.
  • Electrolytes: monitor potassium levels when combined with potassium‑sparing agents.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Icomb 2,5 Mg/2,5 Mg can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • ACE inhibitor with aliskiren: increased risk of renal impairment and hyperkalemia.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia.
  • NSAIDs (e.g., ibuprofen, naproxen): can blunt antihypertensive effect and worsen renal function.
  • Other ACE inhibitors or ARBs: additive risk of hypotension and angioedema.
  • Lithium: may increase lithium levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole): may raise amlodipine concentrations.
  • Diuretics (e.g., thiazides): can enhance hypotensive effect.
  • Other antihypertensives (e.g., beta‑blockers): may require dose adjustment.
  • Grapefruit juice: may increase amlodipine exposure.
  • Antidiabetic agents: blood glucose may improve, risking hypoglycemia.

Frequently Asked Questions

Icomb 2,5 Mg/2,5 Mg is a prescription‑only oral tablet that combines ramipril and amlodipine besilate to treat hypertension. The combination lowers blood pressure by acting on two complementary pathways, making it suitable for adult patients who need additional control beyond monotherapy.

Ramipril is an angiotensin‑converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing vascular tone, decreasing aldosterone‑mediated sodium retention, and helping to lower systemic blood pressure.

The dose of Icomb 2,5 Mg/2,5 Mg is determined by the prescribing clinician based on the patient’s blood pressure, response to therapy, and overall health status. The prescriber will select the appropriate strength and dosing schedule for each individual.

Ramipril, an ACE inhibitor, is contraindicated in pregnancy because it can cause fetal harm. Amlodipine is also not recommended for use while breastfeeding unless the benefit outweighs the risk. Women who are pregnant, planning pregnancy, or nursing should discuss alternative treatments with their healthcare provider.

To request Icomb 2,5 Mg/2,5 Mg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Icomb combines an ACE inhibitor (ramipril) with a calcium‑channel blocker (amlodipine), offering dual‑mechanism blood‑pressure control. Compared with monotherapy, the combination can achieve greater reductions in systolic and diastolic pressure, often with fewer tablets and improved adherence, while maintaining a safety profile similar to the individual agents.

Icomb tablets should be stored below 25 °C in a dry place. Keep them in the original packaging to protect from moisture and light, and ensure they are out of reach of children.

Icomb is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

The most serious risks include angioedema (swelling of the face, lips, tongue, or airway), severe hypotension (dangerously low blood pressure), and hyperkalemia (elevated potassium levels) especially when used with potassium‑sparing agents or in patients with renal impairment.

Icomb should be avoided in patients with a known hypersensitivity to ramipril, amlodipine, or any component of the formulation, in those with a history of angioedema related to ACE inhibitors, and in pregnant women. Caution is also advised for individuals with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Ramipril, Amlodipine Besilate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT