Product image of Icomb 2,5 Mg/2,5 Mg Capsule Rigide (Ramipril, Amlodipine Besilate) supplied by GNH India

Icomb 2,5 Mg/2,5 Mg Capsule Rigide

Active Ingredient:
Ramipril, Amlodipine Besilate
Origin:
EU

Icomb 2,5 Mg/2,5 Mg Capsule Rigide (Ramipril, Amlodipine Besilate)

Ramipril and amlodipine besilate, the active ingredients in Icomb 2,5 Mg/2,5 Mg Capsule Rigide, are an ACE inhibitor and calcium channel blocker presented as a 2.5 mg/2.5 mg hard capsule for oral use. They treat hypertension in adult patients, providing combined blood‑pressure control for essential hypertension.

GNH India supplies Icomb 2,5 Mg/2,5 Mg Capsule Rigide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Icomb combines ramipril and amlodipine besilate to target the renin‑angiotensin system and vascular calcium channels for blood‑pressure management.

  • Hypertension: lowers systolic and diastolic pressure in patients with essential hypertension.
  • Essential hypertension: provides combined therapy to improve overall blood‑pressure control.
  • Cardiovascular risk reduction: helps decrease the risk of stroke and myocardial infarction associated with uncontrolled hypertension.

How It Works

  • Ramipril inhibits angiotensin‑converting enzyme, reducing formation of angiotensin II and decreasing vasoconstriction and aldosterone release. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing arterial vasodilation. The complementary actions result in additive reduction of systemic vascular resistance and blood pressure.

Side Effects

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness: light‑headedness, especially after standing.
  • Peripheral edema: swelling of ankles or feet.
  • Headache: mild to moderate intensity.
  • Flushing: warmth and reddening of skin.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Angioedema: rapid swelling of face, lips, tongue, or throat.
  • Severe hypotension: markedly low blood pressure causing fainting.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Myocardial infarction: chest pain indicative of heart attack.
  • Arrhythmia: irregular heart rhythm.
  • Neutropenia: low white‑blood‑cell count increasing infection risk.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for adverse reactions.

  • Monitor renal function: assess serum creatinine and potassium regularly.
  • Avoid in pregnancy: category D, potential fetal harm.
  • Caution with hepatic impairment: dose adjustment may be required.
  • Concomitant potassium‑sparing diuretics: increased risk of hyperkalemia.
  • Use cautiously in elderly: heightened sensitivity to blood‑pressure lowering effects.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Icomb may interact with several medicines; assess risk before co‑administration.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: risk of renal impairment and hyperkalemia.
  • Concurrent ARBs or other ACE inhibitors: additive effect on potassium and renal function.
  • Potassium supplements or salt substitutes: may cause dangerous hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Diuretics: can enhance hypotensive effect, monitor blood pressure.
  • CYP3A4 inhibitors (e.g., clarithromycin): increase amlodipine plasma levels.
  • CYP3A4 inducers (e.g., rifampicin): reduce amlodipine effectiveness.
  • Beta‑blockers: additive heart‑rate reduction, observe for bradycardia.
  • Lithium: may increase lithium concentrations, monitor serum levels.

Frequently Asked Questions

Icomb 2,5 Mg/2,5 Mg Capsule Rigide is prescribed to lower high blood pressure in adults with essential hypertension. It combines an ACE inhibitor and a calcium‑channel blocker to provide a dual mechanism that improves blood‑pressure control and reduces cardiovascular risk.

Ramipril blocks the conversion of angiotensin I to angiotensin II, decreasing vasoconstriction and aldosterone‑mediated fluid retention. Amlodipine blocks L‑type calcium channels in arterial smooth muscle, causing vasodilation. Together they lower systemic vascular resistance more effectively than either agent alone.

The prescribed dose of Icomb is determined by the treating physician based on the patient’s blood‑pressure readings, renal function, and overall health. The prescriber will select the appropriate strength and dosing schedule for each individual.

Icomb is classified as pregnancy category D, indicating evidence of fetal risk. It should be avoided during pregnancy. Limited data are available for breastfeeding; therefore, use is generally not recommended unless the potential benefit outweighs the risk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Icomb offers a fixed‑dose combination of an ACE inhibitor and a calcium‑channel blocker, which can simplify regimens compared with taking two separate tablets. This dual approach often provides better blood‑pressure control than monotherapy and may reduce pill burden, but individual response and tolerance vary.

Store Icomb capsules at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure the packaging is tightly closed to maintain product stability.

Icomb is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the hard capsule whole; do not crush, chew, or split it.

Serious risks include angioedema, severe hypotension, hyperkalemia, and hepatic dysfunction. Patients should seek immediate medical attention if they experience swelling of the face or throat, fainting, rapid heartbeat, or signs of liver injury such as jaundice.

Icomb should not be used by individuals with a known hypersensitivity to ramipril, amlodipine, or any component of the formulation, patients with hereditary angioedema, or those who are pregnant. Caution is also advised for patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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