Product image of Icomb 5 Mg/5 Mg (Ramipril, Amlodipine Besilate) supplied by GNH India

Icomb 5 Mg/5 Mg

Active Ingredient:
Ramipril, Amlodipine Besilate
Origin:
EU

Icomb 5 Mg/5 Mg (Ramipril, Amlodipine Besilate)

Ramipril, the active ingredient in Icomb 5 Mg/5 Mg, is an ACE inhibitor presented as a 5 mg/5 mg tablet for oral use. It, together with amlodipine besilate, treats hypertension in adults who need combined blood‑pressure control.

GNH India supplies Icomb 5 Mg/5 Mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Icomb 5 Mg/5 Mg combines an ACE inhibitor and a calcium‑channel blocker to manage high blood pressure. It is indicated for:

  • Essential hypertension: lowers systolic and diastolic pressure in adults.
  • Uncontrolled hypertension: provides additional reduction when monotherapy is insufficient.
  • Diastolic hypertension: helps achieve target diastolic values in patients with isolated diastolic elevation.

How It Works

  • Ramipril inhibits angiotensin‑converting enzyme, reducing formation of angiotensin II and decreasing vasoconstriction and aldosterone release. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing arterial vasodilation. The combined actions produce additive blood‑pressure reduction by lowering peripheral resistance and cardiac afterload.

Side Effects

The combination may cause a range of adverse reactions.

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness: especially upon standing.
  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: transient warmth and redness.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, or airway requiring emergency care.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.
  • Myocardial infarction: rare occurrence of heart attack.
  • Neutropenia: low white‑blood‑cell count increasing infection risk.
  • Anaphylaxis: severe allergic reaction with rash, breathing difficulty.

Precautions & Warnings

Before prescribing Icomb 5 Mg/5 Mg, clinicians should consider several safety factors.

  • Pregnancy: category D; avoid unless benefits outweigh risks.
  • Renal impairment: monitor kidney function and adjust dose if needed.
  • Hepatic impairment: use with caution; liver function tests recommended.
  • Electrolyte imbalance: watch serum potassium, especially with diuretics.
  • Concomitant ACE inhibitors or ARBs: increased risk of hyperkalemia and renal dysfunction.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Icomb 5 Mg/5 Mg can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: risk of renal failure and hyperkalemia.
  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • Lithium: increased lithium levels and toxicity.
  • NSAIDs: can blunt antihypertensive effect and affect renal function.
  • Concurrent ACE inhibitors or ARBs: heightened risk of hypotension and renal impairment.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: additive blood‑pressure lowering effect.
  • Thiazide diuretics: may enhance hypotensive response.
  • CYP3A4 inhibitors (e.g., erythromycin): can increase amlodipine concentrations.
  • CYP3A4 inducers (e.g., rifampicin): may reduce amlodipine efficacy.
  • Antidiabetic agents: blood‑glucose levels may fall, requiring dose adjustment.

Frequently Asked Questions

Icomb 5 Mg/5 Mg is a prescription tablet that combines ramipril and amlodipine besilate to treat hypertension. The dual action helps lower blood pressure in adults who need more than a single‑agent therapy to reach target levels.

Ramipril blocks the angiotensin‑converting enzyme, which reduces the production of angiotensin II, a potent vasoconstrictor. This leads to relaxed blood vessels, lower peripheral resistance, and decreased blood pressure.

The appropriate dose of Icomb 5 Mg/5 Mg is determined by the prescribing clinician based on the patient’s blood‑pressure goals, response, and any comorbid conditions. Patients should follow the prescriber’s instructions exactly.

Icomb 5 Mg/5 Mg is classified as pregnancy category D, indicating evidence of risk to the fetus. It should be used only if the potential benefit justifies the risk. Safety during breastfeeding has not been established, so caution is advised.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent ACE inhibitors or calcium‑channel blockers, Icomb offers combined blood‑pressure control in one tablet, which can improve adherence and provide additive BP reduction. It is often chosen when monotherapy does not achieve target pressures.

Store tablets at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct light. Keep out of reach of children and do not use if the packaging is damaged.

Icomb 5 Mg/5 Mg is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew it.

Serious risks include angioedema (swelling of the face, lips, tongue or airway), severe hypotension, and hepatic dysfunction. Patients should seek immediate medical attention if they experience sudden swelling, dizziness, or signs of liver injury.

Icomb should be avoided in patients with known hypersensitivity to ramipril, amlodipine, or any excipients, as well as in those with a history of angioedema related to ACE‑inhibitor therapy. Caution is also required in severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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