Product image of Icomb 5 Mg/5 Mg Capsule Rigide (Ramipril, Amlodipine Besilate) supplied by GNH India

Icomb 5 Mg/5 Mg Capsule Rigide

Active Ingredient:
Ramipril, Amlodipine Besilate
Origin:
EU

Icomb 5 Mg/5 Mg Capsule Rigide (Ramipril, Amlodipine Besilate)

Ramipril, the active ingredient in Icomb 5 Mg/5 Mg Capsule Rigide, is an ACE inhibitor presented as a 5 mg/5 mg capsule for oral use. It reduces high blood pressure and is indicated for adult patients with hypertension, often in combination with a calcium‑channel blocker.

GNH India supplies Icomb 5 Mg/5 Mg Capsule Rigide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare providers worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Icomb, containing ramipril and amlodipine, is used to manage conditions within the hypertension disease family.

  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Essential hypertension: provides effective blood‑pressure control when monotherapy is insufficient.
  • Cardiovascular risk reduction in hypertensive patients: helps prevent stroke and myocardial infarction by maintaining target blood pressure.

How It Works

  • Ramipril inhibits angiotensin‑converting enzyme, decreasing formation of angiotensin II and thereby reducing vasoconstriction and aldosterone‑mediated fluid retention. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing arterial dilation. The combined effect results in lowered systemic vascular resistance and blood pressure.

Side Effects

Icomb may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Cough
  • Dizziness
  • Headache
  • Peripheral edema
  • Flushing
  • Fatigue

Serious or Rare Side Effects

  • Angioedema
  • Severe hypotension
  • Hepatic dysfunction
  • Myocardial infarction
  • Pancreatitis
  • Anaphylaxis

Precautions & Warnings

When prescribing Icomb, several precautions should be observed to ensure patient safety.

  • Monitor blood pressure: check regularly after initiation and dose changes.
  • Assess renal function: evaluate creatinine and eGFR before and during therapy.
  • Avoid in pregnancy: ACE inhibitors are contraindicated due to fetal risk.
  • Caution with potassium‑sparing diuretics: risk of hyperkalemia.
  • Counsel on orthostatic hypotension: advise patients to rise slowly.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Icomb can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: combined use may increase risk of renal impairment and hyperkalemia.
  • Potassium‑supplement or potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): can raise amlodipine levels leading to hypotension.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: additive blood‑pressure lowering effect, monitor for hypotension.
  • Lithium: ACE inhibitors may increase lithium concentrations, requiring level monitoring.

Frequently Asked Questions

Icomb 5 Mg/5 Mg Capsule Rigide is a fixed‑dose combination of ramipril and amlodipine indicated for the treatment of hypertension, specifically essential hypertension, in adult patients. It helps lower blood pressure by acting on two complementary pathways.

Ramipril is an ACE inhibitor that blocks the conversion of angiotensin I to angiotensin II. This reduces vasoconstriction and aldosterone‑mediated sodium retention, leading to vasodilation and a decrease in blood pressure.

The prescribed dose of Icomb 5 mg/5 mg capsule is determined by the treating physician based on the patient’s blood pressure, response, and tolerability. Dosage adjustments follow clinical guidelines and individual patient needs.

The safety of ramipril/amlodipine during pregnancy has not been established; ACE inhibitors are generally contraindicated because of fetal risk. Use during breastfeeding is not recommended without medical advice.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Combining ramipril with amlodipine provides complementary mechanisms—ACE inhibition and calcium‑channel blockade—resulting in more effective blood‑pressure control than either agent alone, often with lower individual doses and potentially fewer side effects.

Store the capsules at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not refrigerate or freeze the product.

Icomb 5 mg/5 mg capsules are taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the capsule whole; do not crush or chew.

Serious adverse reactions may include angioedema, severe hypotension, and hepatic dysfunction. Patients should seek immediate medical attention if they develop swelling of the face, lips, tongue, or experience a sudden drop in blood pressure.

Individuals with a known hypersensitivity to ramipril, amlodipine, or any excipients, those with severe renal impairment, hyperkalemia, or a history of angioedema should avoid this product. It is also contraindicated in pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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