Product image of Icoziss (Calcium Chloride Dihydrate) supplied by GNH India

Icoziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icoziss (Calcium Chloride Dihydrate)

Calcium Chloride Dihydrate, the active ingredient in Icoziss, is a calcium salt / electrolyte presented as a sterile aqueous solution for extracorporeal use. It is employed to correct low calcium levels and to support cardiac and neuromuscular function during procedures that remove blood from the body.

GNH India supplies Icoziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for import and distribution, ensuring product integrity at each step.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Icoziss is used as an electrolyte replenisher to manage conditions associated with low extracellular calcium.

  • Hypocalcemia: restores serum calcium concentrations to normal ranges, helping to prevent neuromuscular irritability and cardiac dysfunction.
  • Calcium supplementation during extracorporeal procedures: provides calcium ions required for myocardial contractility and coagulation while blood circulates outside the body.
  • Cardiopulmonary bypass surgery: maintains calcium balance to support hemodynamic stability and reduce the risk of arrhythmias.

How It Works

  • Calcium Chloride Dihydrate dissociates in solution to release calcium ions (Ca2+). The increased extracellular Ca2+ concentration restores the gradient needed for voltage‑gated calcium channels, enhances myocardial contractility, stabilises neuronal membranes, and participates in the coagulation cascade. By directly supplying calcium, the product compensates for losses that occur during dialysis, plasma exchange, or cardiopulmonary bypass, thereby normalising electrolyte homeostasis.

Side Effects

Calcium Chloride Dihydrate may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects

  • Infusion site irritation: redness, pain or swelling at the catheter site.
  • Transient hypercalcemia: temporary elevation of serum calcium that usually resolves with monitoring.
  • Hypotension: drop in blood pressure during rapid administration.
  • Nausea or vomiting: gastrointestinal discomfort reported by some patients.

Serious or Rare Side Effects

  • Severe hypercalcemia: can lead to cardiac arrhythmias, renal impairment or neurologic symptoms.
  • Cardiac arrhythmias: ventricular tachycardia or fibrillation triggered by abrupt calcium shifts.
  • Vascular thrombosis: clot formation at the infusion site.
  • Allergic reactions: urticaria, bronchospasm or anaphylaxis.

Precautions & Warnings

When using Icoziss, clinicians should observe specific safety measures to minimise risks.

  • Renal impairment: monitor serum calcium and adjust dose to avoid accumulation.
  • Cardiac disease: watch for arrhythmias and changes in blood pressure during infusion.
  • Concurrent calcium‑containing medications: avoid excessive calcium load.
  • Electrolyte imbalance: correct magnesium and phosphate abnormalities before administration.
  • Pregnancy and lactation: use only if the potential benefit outweighs the risk to mother and fetus.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Calcium Chloride Dihydrate can interact with several drugs, affecting their efficacy or safety.

Major Interactions (Avoid)

  • Digitalis glycosides: increased calcium may enhance toxicity, leading to arrhythmias.
  • Bisphosphonates: calcium can reduce their absorption and therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase calcium excretion, requiring closer monitoring of calcium levels.
  • Calcium channel blockers: additive hypotensive effect may occur.
  • Antacids containing calcium: risk of hypercalcemia when combined.

Frequently Asked Questions

Icoziss is a sterile calcium chloride solution used to replenish calcium ions during extracorporeal therapies, such as dialysis or cardiopulmonary bypass, and to treat clinically significant hypocalcemia in hospital settings.

When administered, Calcium Chloride Dihydrate dissociates into calcium ions that increase extracellular calcium concentration. This supports myocardial contractility, stabilises neuronal membranes, and participates in the coagulation cascade, thereby correcting calcium deficits.

The dose of Icoziss is determined by the prescribing clinician based on the patient’s serum calcium level, the type of extracorporeal procedure, and individual clinical factors. No fixed regimen is provided in public literature.

Safety data for Calcium Chloride Dihydrate in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Icoziss, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Icoziss is a sterile, injectable calcium chloride formulation designed for rapid correction of calcium deficits during extracorporeal procedures, whereas oral calcium salts (e.g., calcium carbonate) are slower‑acting and intended for chronic supplementation. The injectable route offers precise control of serum calcium in acute settings.

Icoziss should be stored below 25 °C in its original container, protected from light and moisture. Before use, inspect the solution for particulate matter or discoloration and ensure aseptic handling according to standard infusion protocols.

Icoziss is administered intravenously via an infusion set during extracorporeal procedures or as a rapid IV push under physician direction. The rate and volume are adjusted according to the patient’s calcium status and the specific clinical scenario.

The most serious risks include severe hypercalcemia, which can cause cardiac arrhythmias, renal failure, or neurologic disturbances, and rare allergic reactions such as anaphylaxis. Continuous monitoring of serum calcium and cardiac rhythm is essential during administration.

Icoziss should be avoided in patients with known hypersensitivity to calcium chloride, uncontrolled hypercalcemia, severe renal failure without dialysis capability, or in those where rapid calcium shifts could exacerbate existing cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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