Product image of Icoziss (Calcium Chloride Dihydrate) supplied by GNH India

Icoziss

Active Ingredient:
Calcium Chloride Dihydrate
Origin:
EU

Icoziss (Calcium Chloride Dihydrate)

Calcium chloride dihydrate, the active ingredient in Icoziss, is a calcium salt presented as a calcium salt for extracorporeal use. It treats hypocalcemia and provides calcium supplementation during dialysis procedures.\n\nGNH India supplies Icoziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, dialysis centres and clinics worldwide.

Manufacturer / TM Owner

Vantive Belgium

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Icoziss is used as an electrolyte replenisher to correct calcium deficits in clinical settings.\n\nHypocalcemia: restores low serum calcium concentrations to normal ranges.\nDialysis‑associated calcium deficiency: supplies calcium during extracorporeal dialysis to maintain mineral balance.\nRenal osteodystrophy management: supports calcium homeostasis in patients with chronic kidney disease.

How It Works

  • Calcium chloride dihydrate dissociates in solution, releasing calcium ions that increase extracellular calcium concentration. The elevated calcium enhances neuronal excitability, muscle contraction, and cardiac electrophysiology, while also providing a substrate for bone mineralization and enzymatic processes that depend on calcium as a cofactor.

Side Effects

  • Icoziss may cause a range of adverse reactions, most of which are related to changes in calcium levels or infusion characteristics.\n\nCommon Side Effects:\n- Transient hypercalcemia: mild elevation of serum calcium after infusion.\n- Infusion site irritation: redness or discomfort at the access point.\n- Nausea or vomiting: gastrointestinal upset following administration.\n- Muscle cramps: involuntary contractions due to calcium shifts.\n- Hypotension: drop in blood pressure during rapid infusion.\n- Metallic taste: temporary alteration in taste perception.\n\nSerious or Rare Side Effects:\n- Severe hypercalcemia: can lead to cardiac arrhythmias or neurological impairment.\n- Cardiac arrhythmia: abnormal heart rhythm associated with calcium excess.\n- Vascular calcification: deposition of calcium in blood vessels with prolonged exposure.\n- Anaphylactic reaction: rare severe allergic response requiring immediate medical attention.\n- Metabolic alkalosis: disturbance in acid‑base balance due to calcium carbonate formation.

Precautions & Warnings

  • Before using Icoziss, clinicians should consider several safety measures to minimize risk.\n\nMonitor serum calcium: check levels before, during, and after infusion.\nAdjust dose in renal impairment: reduce amount for patients with decreased clearance.\nAvoid rapid infusion: administer at recommended flow rates to prevent cardiovascular stress.\nCaution in hypercalcemia: do not use if serum calcium is already elevated.\nAssess cardiac status: evaluate for existing arrhythmias or heart disease.\nStore at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Calcium chloride dihydrate can interact with other medicines, altering their effectiveness or safety.\n\nMajor Interactions (Avoid):\n- Loop diuretics: increase calcium loss, potentially worsening hypocalcemia.\n- Bisphosphonates: may precipitate severe hypocalcemia when calcium levels drop.\n- Digoxin: elevated calcium can enhance digoxin toxicity.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors: may affect renal handling of calcium.\n- NSAIDs: can impair kidney function, influencing calcium balance.\n- Vitamin D analogues: synergistic effect on calcium absorption, requiring monitoring.

Frequently Asked Questions

Icoziss is an electrolyte replenisher that provides calcium ions to patients with hypocalcemia or those requiring calcium supplementation during extracorporeal dialysis. It helps restore normal serum calcium levels and supports physiological processes that depend on calcium.

Calcium chloride dihydrate dissociates into calcium ions when administered. The released calcium raises extracellular calcium concentrations, correcting deficits, supporting muscle contraction, nerve transmission, and cardiac function, and providing a substrate for bone mineralization.

The dose of Icoziss is individualized. The prescribing clinician determines the amount and rate of infusion based on the patient’s serum calcium level, clinical condition, and the specific requirements of the dialysis procedure.

Safety data for calcium chloride dihydrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Icoziss, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Icoziss delivers calcium as calcium chloride dihydrate, which provides rapid elevation of serum calcium levels suitable for extracorporeal use. Compared with oral calcium carbonate or citrate, it offers immediate bioavailability and precise control during dialysis, but requires careful monitoring to avoid hypercalcemia.

Store Icoziss at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is sealed when not in use to maintain stability.

Icoziss is administered via an extracorporeal route, typically added to the dialysis circuit or infused through a dedicated line. The infusion rate and total volume are set by the healthcare professional according to the patient’s calcium requirements and treatment protocol.

The most serious risks include severe hypercalcemia, which can cause cardiac arrhythmias, vascular calcification, and metabolic alkalosis. Anaphylactic reactions, although rare, are also a critical concern and require immediate medical intervention.

Icoziss should not be used in patients with known hypersensitivity to calcium chloride, existing severe hypercalcemia, uncontrolled cardiac arrhythmias, or in those where rapid calcium infusion could exacerbate underlying conditions without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Calcium Chloride Dihydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT