Product image of Icsori (Fluticasone Propionate) supplied by GNH India

Icsori

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Icsori (Fluticasone Propionate)

Fluticasone propionate, the active ingredient in Icsori, is an inhaled corticosteroid presented as an inhalation formulation for inhalation use. It treats asthma and chronic obstructive pulmonary disease in adults and children.
GNH India supplies Icsori as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cipla Europe Nv

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Indications & Clinical Uses

  • Fluticasone propionate is an inhaled corticosteroid used in respiratory disease management.
  • Asthma: improves control of symptoms and reduces the frequency of exacerbations.
  • COPD: decreases airway inflammation and helps lower the risk of flare‑ups.
  • Chronic bronchitis: reduces inflammatory response in the airways, aiding symptom relief.

How It Works

  • Fluticasone propionate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines, and adhesion molecules, leading to reduced recruitment and activation of inflammatory cells in the airway mucosa, thereby decreasing airway edema and hyper‑responsiveness.

Side Effects

Fluticasone propionate may cause a range of adverse reactions.

Common Side Effects

  • Oral thrush (candidiasis)
  • Hoarseness or dysphonia
  • Cough or throat irritation
  • Headache
  • Nasal congestion
  • Dry mouth

Serious or Rare Side Effects

  • Adrenal suppression
  • Pneumonia, especially in COPD patients
  • Severe allergic reactions (anaphylaxis)
  • Decreased bone mineral density with long‑term use
  • Vision changes such as cataracts or glaucoma

Precautions & Warnings

  • When prescribing or using fluticasone propionate, consider the following precautions.
  • Assess infection risk: monitor for signs of respiratory infections.
  • Monitor growth in children: regular height and weight checks are advised.
  • Use a spacer device: helps reduce oropharyngeal deposition and irritation.
  • Avoid abrupt discontinuation: tapering may be needed after prolonged therapy.
  • Consider bone health: evaluate calcium and vitamin D intake for long‑term users.
  • Store at ambient temperature: keep below 25°C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Fluticasone propionate can interact with other medicines; awareness of these interactions helps ensure safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic steroid exposure.
  • Systemic corticosteroids: additive immunosuppressive effects.
  • Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • Short‑acting β2‑agonists: may mask worsening asthma symptoms.
  • Diuretics: potential for hypokalemia when combined with systemic steroids.
  • Ritonavir: may raise fluticasone plasma levels, requiring clinical monitoring.

Frequently Asked Questions

Icsori contains fluticasone propionate, an inhaled corticosteroid indicated for the long‑term management of asthma and chronic obstructive pulmonary disease (COPD). It helps control airway inflammation, reduce symptom frequency, and lower the risk of disease exacerbations in both adult and pediatric patients.

Fluticasone propionate binds to glucocorticoid receptors inside airway cells, altering gene expression to suppress the production of inflammatory cytokines and chemokines. This reduces the activation and migration of inflammatory cells, leading to decreased airway swelling, mucus production, and hyper‑responsiveness.

The specific dose of Icsori is determined by the prescribing clinician based on the patient’s age, disease severity, and response to therapy. Dosage instructions are individualized and should be followed exactly as written on the prescription label.

Safety data for fluticasone propionate in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should discuss individual circumstances with the patient before prescribing.

To request Icsori, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Icsori (fluticasone propionate) is a high‑potency inhaled corticosteroid with strong anti‑inflammatory activity, comparable to other agents such as budesonide or beclomethasone. Its once‑daily dosing and favorable lung deposition profile make it a common choice for maintenance therapy, though individual response and side‑effect profiles may differ.

Store Icsori at ambient temperature, preferably below 25 °C. Keep the inhaler in its original packaging, protect it from moisture and direct sunlight, and ensure the mouthpiece remains clean to maintain dose accuracy.

Icsori is delivered via inhalation using a metered‑dose inhaler or a dry‑powder device, depending on the formulation supplied. Patients should exhale fully, place the device in their mouth, inhale slowly and deeply while actuating the inhaler, then hold their breath for several seconds before exhaling.

Serious risks include adrenal suppression, increased susceptibility to pneumonia (especially in COPD patients), severe allergic reactions, and potential reductions in bone mineral density with long‑term use. Patients should be monitored regularly for signs of these complications.

Icsori is contraindicated in individuals with a known hypersensitivity to fluticasone propionate or any component of the inhaler. It should also be avoided in patients with active, untreated infections of the respiratory tract until the infection is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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