Product image of Idacio (Adalimumab) supplied by GNH India

Idacio

Active Ingredient:
Adalimumab
Origin:
EU

Idacio (Adalimumab)

Adalimumab, the active ingredient in Idacio, is a TNF-alpha inhibitor presented as a 40 mg prefilled syringe for subcutaneous use. It treats autoimmune inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, Crohn’s disease, ulcerative colitis and hidradenitis suppurativa in adult patients.

GNH India supplies Idacio as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Idacio (adalimumab) is a TNF-alpha inhibitor used to manage several chronic inflammatory and autoimmune diseases.

  • Rheumatoid arthritis: reduces joint inflammation and slows structural damage.
  • Psoriatic arthritis: alleviates joint pain and skin lesions.
  • Ankylosing spondylitis: improves spinal mobility and reduces pain.
  • Plaque psoriasis: clears skin plaques and decreases scaling.
  • Crohn's disease: induces and maintains remission of intestinal inflammation.
  • Ulcerative colitis: helps achieve clinical remission and mucosal healing.
  • Hidradenitis suppurativa: decreases lesion count and severity.

How It Works

  • Adalimumab is a fully human monoclonal antibody that selectively binds soluble and membrane-bound tumor necrosis factor-alpha (TNF-α). By neutralizing TNF-α, it prevents activation of TNF receptors on inflammatory cells, thereby inhibiting downstream signaling pathways such as NF-κB that drive cytokine production, leukocyte recruitment, and tissue destruction associated with autoimmune inflammation.

Side Effects

Common Side Effects

  • Injection site reactions (pain, redness, swelling)
  • Upper respiratory tract infections
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Serious infections such as tuberculosis or sepsis
  • Malignancies including lymphoma and skin cancer
  • Hepatic injury or elevated liver enzymes

Precautions & Warnings

Before starting Idacio, consider the following precautions:

  • Screen for latent TB before initiating therapy: perform tuberculin skin test or interferon‑γ release assay.
  • Monitor for signs of infection during treatment: report fever, cough, or unusual symptoms promptly.
  • Assess liver function periodically: check ALT/AST levels.
  • Avoid live vaccines while receiving adalimumab: use inactivated vaccines only.
  • Pregnancy and breastfeeding: discuss risks with healthcare provider; safety data are limited.
  • Store at 2-8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Adalimumab may interact with the following agents:

Major Interactions (Avoid)

  • Live vaccines: may cause severe infection; avoid concurrent use.
  • Concomitant use with other biologic immunosuppressants: increased risk of infection.

Moderate Interactions (Monitor Closely)

  • Methotrexate or azathioprine: may increase immunosuppression, monitor labs.
  • Cyclosporine: may increase risk of infection.
  • Inactivated vaccines: may have reduced efficacy, monitor response.

Frequently Asked Questions

Idacio (adalimumab) is indicated for adult patients with moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, Crohn’s disease, ulcerative colitis, and hidradenitis suppurativa. It is prescribed when conventional therapies have not achieved adequate disease control.

Adalimumab is a fully human monoclonal antibody that binds to tumor necrosis factor‑alpha (TNF‑α), a key cytokine in inflammatory pathways. By neutralising TNF‑α, it blocks the activation of TNF receptors, reducing downstream inflammatory signaling and the resulting tissue damage.

The dosing schedule for Idacio is set by the prescribing clinician based on the specific indication, patient weight, disease severity, and response to therapy. The prescriber decides the frequency and any dose adjustments after evaluating clinical outcomes.

Safety data for adalimumab in pregnancy and lactation are limited. The product is classified as pregnancy category unknown. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Idacio.

To order Idacio, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Idacio (adalimumab) is a fully human monoclonal antibody, whereas agents like etanercept are fusion proteins and infliximab is a chimeric antibody. All target TNF‑α but differ in molecular structure, dosing frequency, and immunogenicity profiles. Choice of therapy depends on clinical response, convenience, and physician preference.

Idacio should be stored refrigerated at 2‑8 °C. Keep the prefilled syringes in the original carton, protect them from light, and do not freeze or shake the product. If temporary temperature excursions occur, consult the product label before use.

Idacio is supplied as a 40 mg prefilled syringe for subcutaneous injection. The injection is given into the thigh, abdomen, or upper arm according to the prescriber’s instructions. Patients should rotate injection sites and follow aseptic technique to minimize local reactions.

The most serious risks include severe infections such as tuberculosis or bacterial sepsis, development of malignancies (e.g., lymphoma, skin cancer), hepatic injury, and rare demyelinating disorders. Patients should be monitored regularly for signs of infection, liver dysfunction, and any new neurological symptoms.

Idacio is contraindicated in individuals with known hypersensitivity to adalimumab or any excipients, active serious infections, untreated latent tuberculosis, or those receiving live vaccines. Caution is also advised for patients with severe heart failure, demyelinating disease, or a history of malignancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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